Evidence map›Paper›PMID 35953431›Full record

Trial reportThe Journal of nutrition2023

DHA Supplementation During Pregnancy Enhances Maternal Vagally Mediated Cardiac Autonomic Control in Humans.

Danielle N Christifano, Lynn Chollet-Hinton, Nicole B Mathis, Byron J Gajewski, Susan E Carlson, John Colombo, Kathleen M Gustafson

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Danielle N ChristifanoDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0001-9368-2028
Lynn Chollet-HintonDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.
Nicole B MathisHoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA.
Byron J GajewskiDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.
Susan E CarlsonDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-3579-1685
John ColomboDepartment of Psychology, Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, KS, USA.
Kathleen M GustafsonHoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-3225-5086
University of Kansas Medical Center · USUniversity of Kansas · US

Funding

Prenatal DHA & Neurofunctional DevelopmentR01HD086001 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUSTAFSON, KATHLEEN M · 2016 to 2020
$3.1M
NICHD NIH HHS 1R01HD086001NICHD NIH HHS R01 HD086001
6 · The paper itself

Abstract

backgroundDHA is an essential omega-3 (ω-3; n-3) fatty acid that has well-established benefits for the fetus. DHA also has the potential to influence the health of the mother, but this area is understudied.

objectivesThe objective of this secondary analysis was to determine if DHA was related to maternal heart rate (HR) and heart rate variability (HRV) metrics in a large cohort of pregnant women.

methodsIn the parent trial (1R01HD086001) eligible participants (≥18 y old, English speaking, carrying a singleton pregnancy, 12-20 wk of gestation) were randomly assigned to consume 200 mg/d or 800 mg/d DHA for the duration of their pregnancy (n = 300). Weight, blood pressure, and magnetocardiograms (MCGs) were collected at 32 wk and 36 wk of gestation (n = 221). Measures of HR and HRV in time-, frequency-, and nonlinear-domains were determined from the isolated maternal MCG. Treatment group and timepoint were examined as predictors in association with HR and HRV metrics using random-intercept mixed-effects ANOVA unadjusted and adjusted models accounting for weight and dietary DHA intake.

resultsWomen receiving the higher dose of DHA (800 mg/d) during pregnancy had lower HR, lower sympathetic index, higher vagally mediated HRV indices, and greater HRV complexity when compared with the women who received the lower dose (200 mg/d; all P < 0.05). All the dose relations remained significant even after controlling for the effect of time, maternal weight, and dietary DHA intake.

conclusionsDHA supplementation increases vagal tone in pregnant women. Longitudinal studies examining the potential link between DHA, enhanced vagal tone, and reported reduction in early preterm birth are warranted.

Indexed as

Fatty Acids, Omega-3Premature BirthDietary SupplementsDocosahexaenoic AcidsFemaleHumansInfant, NewbornMothersPregnancyDocosahexaenoic AcidsFatty Acids, Omega-3dietary supplementsdocosahexaenoic acidfatty acidsfemaleheart rate variabilitypregnancy

Identifiers

PMID35953431
PMCPMC9839999
OpenAlexW4291012186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.