Evidence map›Paper›PMID 35953305›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer Disease.

Shaney Flores, Charles D Chen, Yi Su, Aylin Dincer, Sarah J Keefe, Nicole S McKay, Angela M Paulick, Gloria Guzman Perez-Carrillo, Liang Wang, Russ C Hornbeck and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 17 citations in OpenAlex.

  1. Associations of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Tau-PET and CSF MTBR-tau243 comparisons validate increased tau aggregation in females.European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Age predicts Alzheimer's in Down syndrome better than MRI, plasma, or cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Review
  7. Head-to-head comparison of tau PET tracers [Alzheimer's research & therapy · 2024
    Article
  8. Article
  9. Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?International journal of molecular sciences · 2024
    Review
  10. Review
  11. Test-retest performance of [Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  12. Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  13. MRI-free processing of tau PET images for early detection.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Shaney FloresDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Charles D ChenDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Yi SuBanner Alzheimer's Institute, Phoenix, Arizona.
Aylin DincerDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Sarah J KeefeDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Nicole S McKayDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Angela M PaulickDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Gloria Guzman Perez-CarrilloDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Liang WangDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Russ C HornbeckDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Manu GoyalDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Andrei VlassenkoDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Sally SchwarzDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Michael L NickelsDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Dean F WongDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Zhude TuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Jonathan E McConathyUniversity of Alabama at Birmingham, Birmingham, Alabama.
John C MorrisDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri.
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Brian A GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri; bagordon@wustl.edu.
Washington University in St. Louis · USHope Center for Neurological Disorders · USBanner Alzheimer’s InstituteUniversity of Alabama at Birmingham · US

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
Dominantly Inherited Alzheimer's Network Trials Unit - Adaptive Prevention TrialR01AG046179 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2019
$26.6M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI HEATHER Allyson BIMONTE-NELSON · 2021 to 2026
$24.9M
PET, APOE & the Preclinical Course of Alzheimer's DiseaseR01AG031581 · NIA · BANNER ALZHEIMER'S INSTITUTE · PI CASELLI, RICHARD J., REIMAN, ERIC MICHAEL · 2008 to 2018
$16.6M
Alzheimer's Prevention Initiative ADAD Colombia TrialR01AG055444 · NIA · BANNER HEALTH · PI LOPERA, FRANCISCO, REIMAN, ERIC MICHAEL · 2017 to 2022
$14.9M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
DOMINANTLY INHERITED ALZHEIMER NETWORK TRIAL: AN OPPORTUNITY TO PREVENT DEMENTIAU01AG042791 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2013 to 2018
$8.9M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G, MARCUS, DANIEL SCOTT · 2016 to 2019
$2.4M
Multidisciplinary Training in Alzheimer and Related DementiasT32AG058518 · NIA · WASHINGTON UNIVERSITY · PI Eric Martin McDade, Barbara Joy Snider · 2018 to 2026
$2.3M
NCATS NIH HHS UL1 TR000448NIA NIH HHS K01 AG053474NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG031581NIA NIH HHS R01 AG046179NIA NIH HHS R01 AG055444NIA NIH HHS RF1 AG073424NIA NIH HHS T32 AG058518NIA NIH HHS U01 AG042791NIBIB NIH HHS R01 EB009352NIH HHS S10 OD025214NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

Off-target binding of [

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloidAmyloid beta-PeptidesAniline CompoundsBrainCarbolinesFemaleHumansMalePositron-Emission TomographySkulltau ProteinsThiazoles2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloidAmyloid beta-PeptidesAniline CompoundsCarbolinestau ProteinsThiazolesamyloid PEThumanoff-target bindingtau PET

Identifiers

PMID35953305
PMCPMC9902848
OpenAlexW4290999806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.