ArticleBritish journal of sports medicine2022
Dose-response association of aerobic and muscle-strengthening physical activity with mortality: a national cohort study of 416 420 US adults.
Article in British journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of exhaustive and/or strenuous exercise on aging-related molecular and physiological biomarkers: a systematic review and meta-analysis.Biogerontology · 2026Pooled it
- Temporal Variations and Sociodemographic Differences in no Muscle-Strengthening Exercise Among Adolescents: A 10-Year Repeated Cross-Sectional Study.Scandinavian journal of medicine & science in sports · 2026Article
- Smartphone-Based Physical Activity Program to Reduce "Chemo-Brain" Symptoms and Improve Health in Cancer Survivors With and Without Type 2 Diabetes: Protocol for a Single-Arm Pre-Post Pilot Trial.JMIR research protocols · 2025Article
- Perspectives on whole body and tissue-specific metabolic flexibility and implications in cardiometabolic diseases.Cell reports. Medicine · 2025Review
- Vigorous But Not Moderate Physical Activity Is Associated With Reduced Cardiovascular Disease Risk In Young Hispanic Men.The American journal of cardiology · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Comparison of Acute Orthopaedic Injuries From Cardiovascular Versus Strength Exercise in Adolescents and Young Adults to the Emergency Department: An Analysis of the National Electronic Injury Surveillance System Database, 2018-2022.Orthopaedic journal of sports medicine · 2025Article
- Article
- Editorial: Optimal physical activity across the lifespan for people of all abilities.Frontiers in sports and active living · 2025Article
- Dual modulation of atherosclerosis by exercise and metformin: convergent pathways, divergent outcomes, and therapeutic potential.Clinical hypertension · 2025Review
- Weight training and risk of all-cause, cardiovascular disease and cancer mortality among older adults.International journal of epidemiology · 2024Article
- Leisure-time physical activity and mortality from influenza and pneumonia: a cohort study of 577 909 US adults.British journal of sports medicine · 2023Article
- Identifying the sociodemographic and work-related factors related to workers' daily physical activity using a decision tree approach.BMC public health · 2023Article
- Prospective Associations of Different Combinations of Aerobic and Muscle-Strengthening Activity With All-Cause, Cardiovascular, and Cancer Mortality.JAMA internal medicine · 2023Article
- Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023Review
- Aerobic and Muscle-Strengthening Physical Activity, Television Viewing, and Nonalcoholic Fatty Liver Disease: The CARDIA Study.Journal of clinical medicine · 2023Article
- Aerobic, muscle-strengthening, and flexibility physical activity and risks of all-cause and cause-specific mortality: a population-based prospective cohort of Korean adults.BMC public health · 2023Article
- Meeting guidelines for physical activity, muscle strength, and sleep lowers mortality risk: Commentary on: "Associations between aerobic and muscle-strengthening physical activity, sleep duration, and risk of all-cause mortality: A prospective cohort study of 282,473 U.S. adults".Journal of sport and health science · 2023Article
- Objectively Measured Physical Activity Is Lower in Individuals with Normal Weight Obesity in the United States.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesTo investigate the dose-response association of aerobic physical activity (PA) and muscle-strengthening exercise (MSE) with all-cause mortality.
methodsNational Health Interview Survey data (1997-2014) were linked to the National Death Index through 2015, which produced a cohort of 416 420 US adults. Cox proportional-hazard models were used to estimate HRs and 95% CIs for the associations of moderate aerobic PA (MPA), vigorous aerobic PA (VPA) and MSE with mortality risk. Models controlled for age, sex, race-ethnicity, income, education, marital status, survey year, smoking status, body mass index and chronic conditions.
resultsRelative to those who engaged in no aerobic PA, substantial mortality risk reduction was associated with 1 hour/week of aerobic PA (HR: 0.85, 95% CI: 0.83 to 0.86) and levelled off at 3 hours/week of aerobic PA (0.73, 0.71 to 0.75). Similar results were observed for men and women and for individuals younger and older than 60 years. MSE conferred additional mortality risk reduction at 1 time/week (0.89, 0.81 to 0.97) and appeared no longer beneficial at 7 times/week (0.99, 0.94 to 1.04).
conclusionThe minimum effective dose of aerobic PA for significant mortality risk reduction was 1 hour/week of MPA or VPA, with additional mortality risk reduction observed up to 3 hours/week. For older adults, only small decreases in mortality risk were observed beyond this duration. Completing MSE in combination with aerobic PA conferred additional mortality risk reduction, with a minimum effective dose of 1-2 times/week.
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Registered trials
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