ReviewJournal of the American College of Cardiology2022
Mitral Valve Dysfunction in Patients With Annular Calcification: JACC Review Topic of the Week.
Review in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Comparison of different timings of percutaneous coronary intervention in patients with transcatheter aortic valve implantation: a network meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Mitral annulus calcification and the risk of infective endocarditis: insights from DANCAVAS screening trials.European heart journal open · 2026Article
- Association of left ventricular global longitudinal strain with outcomes of severe mitral regurgitation due to severe mitral annular calcification: a retrospective cohort study.Cardiovascular diagnosis and therapy · 2026Article
- Robotic mitral valve repair in the setting of mitral annular calcification: the value of repair, the valor of judgment.Journal of thoracic disease · 2026Article
- Beyond the Coronaries: Utility of Extra-Coronary Calcification for Cardiovascular Risk Assessment in Women.Current atherosclerosis reports · 2026Review
- Contemporary Transcatheter Approaches to Mitral Regurgitation.Reviews in cardiovascular medicine · 2026Review
- Calcium Disorders in Rheumatic Diseases: An Overlooked Problem With Major Clinical Implications.Cureus · 2026Review
- Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease.Journal of the American Heart Association · 2026Article
- Article
- Pearls and pitfalls in the diagnosis and management of mitral annular calcification.Heart (British Cardiac Society) · 2026Article
- Impact of left-heart myopathy on mitral valve stenosis assessment and interventional outcomes: anEuropean heart journal. Digital health · 2026Article
- Impact of mitral annular calcification in mitral valve surgery: 25-year Mayo Clinic experience.Annals of cardiothoracic surgery · 2025Article
- Early and late outcomes of mitral valve surgery in the setting of mitral annular calcification: a systematic review with narrative synthesis.Annals of cardiothoracic surgery · 2025Article
- Transcatheter mitral valve options for severe mitral annular calcification.Annals of cardiothoracic surgery · 2025Review
- Mitral annular calcification: implications on clinical outcomes and interventions.Annals of cardiothoracic surgery · 2025Review
- A rare presentation of a rare problem: mitral annular calcification-related calcific amorphous tumour with cavitation and left ventricle to left atrium communication-a case report.European heart journal. Case reports · 2025Article
- The Emerging Role of Lithotripsy in Structural Heart Interventions.Current cardiology reports · 2025Review
- The atrial neoannulus technique for mitral valve replacement in patients with severe mitral annular calcification.JTCVS techniques · 2025Article
- Intravascular Lithotripsy in Mitral Annulus Calcification-Related Mitral Stenosis: Hope or Hype?Structural heart : the journal of the Heart Team · 2025Article
- Mitral Annular Calcification: Natural History, Prognosis, and Clinical Outcomes.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Mitral annular calcification (MAC) is a common clinical finding and is associated with adverse clinical outcomes, but the clinical impact of MAC-related mitral valve (MV) dysfunction remains underappreciated. Patients with MAC frequently have stenotic, regurgitant, or mixed valvular disease, and this valvular dysfunction is increasingly recognized to be independently associated with worse prognosis. MAC-related MV dysfunction is a distinct pathophysiologic entity, and importantly much of the diagnostic and therapeutic paradigm from published rheumatic MV disease research cannot be applied in this context, leaving important gaps in our knowledge. This review summarizes the current epidemiology, pathophysiology, diagnosis, and classification of MAC-related MV dysfunction and proposes both an integrative definition and an overarching approach to this important and increasingly recognized clinical condition.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.