Evidence map›Paper›PMID 35953021›Full record

ArticleOphthalmology. Glaucoma

Glaucoma Medication Adherence 1 Year after the Support, Educate, Empower Personalized Glaucoma Coaching Program.

Olivia J Killeen, Leslie M Niziol, Juno Cho, Michele Heisler, Ken Resnicow, Deborah Darnley-Fisch, David C Musch, Paul P Lee, Paula Anne Newman-Casey

Open access · greenAbstract read
In one paragraph

Article in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Olivia J KilleenDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Leslie M NiziolDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Juno ChoDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Michele HeislerDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Ken ResnicowDepartment of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Deborah Darnley-FischDepartment of Ophthalmology, Henry Ford Health System, Detroit, Michigan.
David C MuschDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Michigan, Ann Arbor, Michigan; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Paul P LeeDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Paula Anne Newman-CaseyDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Michigan, Ann Arbor, Michigan. Electronic address: panewman@med.umich.edu.
University of Michigan · USMichigan Department of Health and Human Services · USHenry Ford Health System · US

Funding

Support, Educate, Empower: The SEE Personalized Glaucoma Coaching Trial: Diversity SupplementR01EY031337 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN-CASEY, PAULA ANNE · 2020 to 2024
$3.9M
Sustainable Community Clinic Telemedicine-Based Glaucoma ScreeningU01DP006442 · DP · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN-CASEY, PAULA ANNE · 2019 to 2023
$3.5M
Improving glaucoma self-management with technology-supported counselorsK23EY025320 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN-CASEY, PAULA ANNE · 2016 to 2019
$920k
Glaucoma progression ? Modeling its trajectory and contributing factors: evidence from AGIS and CIGTSR21EY028997 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUSCH, DAVID C · 2018 to 2019
$442k
Insights on Glaucoma from Analysis of the CIGTS DataR21EY020912 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUSCH, DAVID C · 2011 to 2012
$426k
NCCDPHP CDC HHS U01 DP006442NEI NIH HHS K23 EY025320NEI NIH HHS R01 EY031337NEI NIH HHS R21 EY020912NEI NIH HHS R21 EY028997
6 · The paper itself

Abstract

purposeTo assess the efficacy of the Support, Educate, Empower (SEE) glaucoma coaching program on medication adherence among poorly adherent patients with glaucoma for 12 months after cessation of the intervention.

designUncontrolled intervention study with a pre-post design.

participantsThe SEE cohort was recruited from the University of Michigan and included patients with glaucoma aged ≥ 40 years, taking ≥ 1 medication, who self-reported poor adherence. Electronic medication monitoring of those who completed the program continued for up to 1 year after the coaching intervention.

methodsAdherence was monitored electronically (AdhereTech) during the 7-month program and 12-month follow-up period. Adherence was the percentage of doses taken on time. Participants were censored for surgery, change in glaucoma medications, or adherence monitor disuse. The SEE program included automated medication reminders, 3 in-person motivational interviewing-based counseling sessions with a glaucoma coach, and 5 phone calls with the coach for between-session support. There was no contact between the study team and participants during the 12-month follow-up after program cessation. Baseline participant characteristics were summarized with descriptive statistics. Paired t tests and Wilcoxon signed rank tests were used to investigate significant changes in monthly adherence during follow-up.

main outcome measuresChange in electronically monitored medication adherence over the 12 months following the conclusion of the SEE program.

resultsOf 48 participants, 39 (81%) completed the SEE program and continued electronic medication monitoring for up to 1 year after program cessation. The mean age of the participants was 64 years (standard deviation [SD], 10); of the 39 participants, 56% were male, 49% were Black, and 44% were White. The mean length of follow-up was 284 days (SD, 110; range, 41-365 days). Censoring occurred in 18 (56%) participants. The mean adherence during the follow-up period was 67% (SD, 22%). This was significantly lower than the adherence during the SEE program (mean, 81%; SD, 18%; P < 0.0001) but significantly higher than the baseline preprogram adherence (mean, 60%; SD, 18%; P = 0.0393). The largest monthly losses occurred at months 1 (mean, 7%; P = 0.0001) and 4 (mean, 6%; P = 0.0077).

conclusionsGlaucoma medication adherence decreased significantly in the year after cessation of the SEE coaching program but remained significantly higher than baseline adherence. To maintain excellent long-term medication adherence, intermittent reinforcement sessions may be necessary.

Indexed as

GlaucomaMentoringAntihypertensive AgentsFemaleHumansMaleMedication AdherenceMiddle AgedSelf ReportAntihypertensive AgentsGlaucomaLong-term follow-upMedication adherence

Identifiers

PMID35953021
PMCPMC10246914
OpenAlexW4293246619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.