ArticleThe Science of the total environment2022
Hand nicotine as an independent marker of thirdhand smoke pollution in children's environments.
Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Analysis of Assessment Methods for Detecting Nicotine Residue and Its Impact on Humans: A Systematic Review.International journal of environmental research and public health · 2025Pooled it
- Quantitative reference levels for thirdhand smoke residue from tobacco products in indoor environments: a systematic review and meta-analysis.Journal of exposure science & environmental epidemiology · 2026Review
- Evaluation of Therapeutic Opioids in Skin-Derived Matrices (Sweat and Sebum) of Neonatal and Pediatric Patients and Their Role in Opioid Incorporation Into Hair.Drug testing and analysis · 2026Article
- Urinary cotinine cut-offs for tobacco smoke exposure in pregnancy and associations with child intelligence quotient: A multi-cohort analysis.International journal of hygiene and environmental health · 2026Article
- Article
- Assessment, detection, and validation of clinical associations of thirdhand smoke exposure (ADVOCATE) study protocol.Pediatric research · 2025Article
- Trends in academic research on thirdhand smoke using bibliometric analysis.Tobacco induced diseases · 2025Review
- Policy-relevant differences between secondhand and thirdhand smoke: strengthening protections from involuntary exposure to tobacco smoke pollutants.Tobacco control · 2024Article
- Effects of Environmental Tobacco Smoke on Oxidative Stress in Childhood: A Human Biomonitoring Study.Toxics · 2024Article
- Contamination of surfaces in children's homes with nicotine and the potent carcinogenic tobacco-specific nitrosamine NNK.Journal of exposure science & environmental epidemiology · 2024Article
- Cotton pillow samplers for assessment of thirdhand smoke in homes of smokers and nonsmokers with children.Journal of environmental exposure assessment · 2024Article
- Changes and stability of hand nicotine levels in children of smokers: Associations with urinary biomarkers, reported child tobacco smoke exposure, and home smoking bans.Environment international · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundHand nicotine (HN) levels measure children's exposure to tobacco smoke pollutants from thirdhand and secondhand smoke. HN is associated with urinary and salivary cotinine, but the associations of HN with other tobacco smoke exposure (TSE) markers remain unknown.
objectivesWe compared levels of HN and four urinary TSE biomarkers: cotinine, trans-3'-hydroxycotinine (3HC), nicotelline N-oxides, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and children's sociodemographic and TSE patterns. We also examined if HN is a plausible pathway for children's exposure to active smoking.
methodsData were collected from 175 non-smoking patients (Mean (SD) age = 5.4 (3.4) years) who lived with ≥1 cigarette smoker(s). HN and TSE biomarker levels were determined using LC-MS/MS. Multivariate and multivariable regression analyses were conducted to examine associations between TSE markers and parent-reported measures, controlling for sociodemographics.
resultsOf the five markers of TSE, cotinine (R DISCUSSION: HN levels were associated with modifiable tobacco-related behaviors and shows promise as a marker of sources of THS pollution in a child's environment not captured by measurement of urinary cotinine alone. HN levels provide additional information about TSE, complementing other biomarkers when assessing children's overall TSE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.