Evidence map›Paper›PMID 35952858›Full record

ArticleThe Annals of thoracic surgery2023

Dose Effect of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass.

Kei Kobayashi, Takuya Maeda, Mobolanle Ayodeji, Shao Ching Tu, Alice Chen, May Rajtboriraks, Chao-Hsiung Hsu, Tsang-Wei Tu, Paul C Wang, Patrick J Hanley and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Annals of thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Kei KobayashiDepartment of Cardiac Surgery, Children's National Hospital, Washington, DC; Center for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC.
Takuya MaedaDepartment of Cardiac Surgery, Children's National Hospital, Washington, DC; Center for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC.
Mobolanle AyodejiCenter for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC.
Shao Ching TuCenter for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri.
Alice ChenCenter for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC; George Washington University, School of Medicine and Health Sciences, George Washington University, Washington, DC.
May RajtboriraksCenter for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC; Department of Biomedical Engineering, The Catholic University of America, Washington, DC.
Chao-Hsiung HsuMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC.
Tsang-Wei TuMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC.
Paul C WangMolecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC; Department of Electrical Engineering, Fu Jen Catholic University, Taipei, Taiwan.
Patrick J HanleyDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC; Program for Cell Enhancement and Technologies for Immunotherapy, Division of Blood and Marrow Transplantation, Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC.
Richard A JonasDepartment of Cardiac Surgery, Children's National Hospital, Washington, DC; Center for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC.
Nobuyuki IshibashiDepartment of Cardiac Surgery, Children's National Hospital, Washington, DC; Center for Neuroscience Research, Children's National Hospital, Washington, DC; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC; Department of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address: nishibas@childrensnational.org.
Children's National · USHoward University · USFu Jen Catholic University · TWGeorge Washington University · USGeorge Washington University Hospital · US

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI BYRON D. FORD · 2019 to 2026
$37.7M
Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI LAUREN KENWORTHY · 2021 to 2026
$9.3M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Cell Therapy for Neuroprotection in Congenital Heart DiseaseR01HL139712 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI Nobuyuki Ishibashi · 2018 to 2026
$5.7M
White Matter Protection in the Fetus with Congenital Heart DiseaseR01HL146670 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI ISHIBASHI, NOBUYUKI · 2020 to 2023
$3.3M
Mesenchymal Stromal Cell Delivery through Cardiopulmonary Bypass in Pediatric Cardiac SurgeryR33HL146394 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI BOLLARD, CATHERINE M., ISHIBASHI, NOBUYUKI · 2019 to 2021
$2.6M
In vivo MRI Measures of Brain Metabolism in Traumatic Brain InjuryR01NS123442 · NINDS · HOWARD UNIVERSITY · PI Tsang-Wei Tu · 2022 to 2026
$1.9M
The developmental origins and fate of neurons in the gyrencephalic neocortexR21NS127051 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI HAYDAR, TARIK F, ISHIBASHI, NOBUYUKI · 2022 to 2023
$491k
Molecular Regulation of UreagenesisK01DK076846 · NIDDK · CHILDREN'S RESEARCH INSTITUTE · PI CALDOVIC, LJUBICA MORIZONO · 2008 to 2010
$323k
NHLBI NIH HHS R01 HL139712NHLBI NIH HHS R01 HL146670NHLBI NIH HHS R33 HL146394NICHD NIH HHS P50 HD105328NICHD NIH HHS U54 HD090257NIDDK NIH HHS K01 DK076846NIMHD NIH HHS U54 MD007597NINDS NIH HHS R01 NS123442NINDS NIH HHS R21 NS127051
6 · The paper itself

Abstract

backgroundNeurologic impairments are a significant concern for survivors after pediatric cardiac surgery with cardiopulmonary bypass (CPB). We have previously shown that mesenchymal stromal cell (MSC) delivery through CPB has the potential to mitigate the effects of CPB on neural stem/progenitor cells. This study assessed the dose effects of MSCs.

methodsPiglets (n = 20) were randomly assigned to 1 of 4 groups: control, CPB, or CPB followed by MSC administration with low and high doses (10 × 10

resultsBy magnetic resonance imaging, approximately 10 times more MSCs were detected within the entire brain after high-dose delivery than after low-dose delivery. No adverse events affecting hemodynamics, various biomarkers, and neuroimaging were detected after high-dose MSC delivery. High-dose MSCs significantly increased circulating levels of interleukin 4 after CPB. Both MSC groups normalized microglia activation after CPB, demonstrating MSC-induced reduction in cerebral inflammation. There was a significant increase in neuroblasts in the subventricular zone in both treatment groups. The thickness of the most active neurogenic area within the subventricular zone was significantly increased after high-dose treatment compared with CPB and low-dose MSCs, suggesting dose-dependent effects on the neurogenic niche.

conclusionsMSC delivery through CPB is feasible up to 100 × 10

Indexed as

Cardiac Surgical ProceduresMesenchymal Stem CellsAnimalsBrainCardiopulmonary BypassChildHumansInflammationSwine

Identifiers

PMID35952858
PMCPMC10009803
OpenAlexW4292022514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.