ArticleCell reports2022
Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
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Who cites it
39 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- Characterization of Bronchiolitis and Vaccine-induced Enhanced Respiratory Disease in Syrian Hamsters Caused by Respiratory Syncytial Virus Infection.The Journal of infectious diseases · 2026Article
- Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice.Journal of virology · 2026Article
- TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data.Genome biology · 2026Article
- Skeletal muscle as a dynamic immunological niche for vaccination.Frontiers in immunology · 2026Review
- Recombinant Bacillus subtilis spores expressing SARS-CoV-2 spike protein induced humoral, mucosal, and cellular immunity in mice.Scientific reports · 2025Article
- Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters.Communications biology · 2025Article
- Adjuvant-dependent protection of SARS-CoV-2 spike vaccines: comparative immunogenicity of human-applicable formulations.Journal of virology · 2025Article
- Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice.bioRxiv : the preprint server for biology · 2025Article
- Hamsters immunized with formalin-inactivated SARS-CoV-2 develop accelerated lung histopathological lesions and Th2-biased response following infection.NPJ vaccines · 2025Article
- Differential efficacy of first licensed western vaccines protecting without immunopathogenesis Wuhan-1-challenged hamsters from severe COVID-19.NPJ vaccines · 2025Article
- Combined immunization with SARS-CoV-2 spike and SARS-CoV nucleocapsid protects K18-hACE2 mice but increases lung pathology.NPJ vaccines · 2025Article
- Virus-like particles containing the extracellular domain of G protein in combination with a CTL peptide of M2 elicit protection against respiratory syncytial virus infection without pulmonary disease.Frontiers in immunology · 2025Article
- Article
- Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies.Emerging microbes & infections · 2024Article
- Safety and Immunogenicity Study of a Bivalent Vaccine for Combined Prophylaxis of COVID-19 and Influenza in Non-Human Primates.Vaccines · 2024Article
- Ally, adversary, or arbitrator? The context-dependent role of eosinophils in vaccination for respiratory viruses and subsequent breakthrough infections.Journal of leukocyte biology · 2024Review
- Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Biomarkers associated with vaccine-associated enhanced respiratory disease following influenza A virus infection in swine.Veterinary immunology and immunopathology · 2024Article
- Article
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Authors and funding
27 authors at 11 institutions in 1 country.
Aileen EbenigProduct Testing of IVMPs, Div. of Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Samada MuraleedharanProduct Testing of IVMPs, Div. of Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Julia KazmierskiInstitute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Daniel TodtDepartment for Molecular and Medical Virology, Ruhr-University, 44801 Bochum, Germany; European Virus Bioinformatics Center (EVBC), 07743 Jena, Germany.
Arne AusteProduct Testing of IVMPs, Div. of Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany; German Center for Infection Research, Gießen-Marburg-Langen, Germany.
Martina AnzagheDiv. of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
André GömerDepartment for Molecular and Medical Virology, Ruhr-University, 44801 Bochum, Germany; Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Dylan PostmusInstitute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Patricia GogeschDiv. of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Marc NilesDiv. of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Roland PleskerAnimal Facilities, Div. Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Csaba MiskeyDiv. of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Michelle Gellhorn SerraInstitute for Virology, Phillipps-University, 35043 Marburg, Germany.
Angele BreithauptDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.
Cindy HörnerProduct Testing of IVMPs, Div. of Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany; German Center for Infection Research, Gießen-Marburg-Langen, Germany.
Carina KruipProduct Testing of IVMPs, Div. of Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Rosina EhmannInstitute for Microbiology, Bundeswehr, 80937 München, Germany.
Zoltan IvicsDiv. of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Zoe WaiblerDiv. of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Stephanie PfaenderDepartment for Molecular and Medical Virology, Ruhr-University, 44801 Bochum, Germany.
Emanuel WylerBerlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany.
Markus LandthalerBerlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany; IRI Life Sciences, Institute for Biology, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.
Alexandra KupkeGerman Center for Infection Research, Gießen-Marburg-Langen, Germany; Institute for Virology, Phillipps-University, 35043 Marburg, Germany.
Geraldine NouaillesDivision of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Christine GoffinetInstitute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Richard J P BrownVirus Tropism and Immunogenicity, Div. of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Michael D MühlebachProduct Testing of IVMPs, Div. of Veterinary Medicines, Paul-Ehrlich-Institut, 63225 Langen, Germany; German Center for Infection Research, Gießen-Marburg-Langen, Germany. Electronic address: michael.muehlebach@pei.de.
Paul Ehrlich Institut · DECharité - Universitätsmedizin Berlin · DEGerman Center for Infection Research · DEPhilipps University of Marburg · DERuhr University Bochum · DEFreie Universität Berlin · DEFriedrich-Loeffler-Institut · DEHumboldt-Universität zu Berlin · DEMax Delbrück Center · DEUniversität der Bundeswehr München · DEUniversity of Veterinary Medicine Hannover, Foundation · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some respiratory infections. To investigate the potential for VAERD induction in coronavirus disease 2019 (COVID-19), we evaluate two vaccine leads utilizing a severe hamster infection model: a T helper type 1 (T
Indexed as
COVID-19VaccinesAnimalsAntibodies, ViralCricetinaeCytokinesImmunizationLungMiceMice, Inbred BALB CTh1 CellsTh2 CellsVaccinationAntibodies, ViralCytokinesVaccinesADEantibody-dependent enhancementCOVID-19 vaccinesCP: ImmunologyCP: Microbiologydexamethasone treatmentmechanism of immunopathogenesisprotein vaccinesTH2 immune responsesvaccine-associated enhanced respiratory diseasevaccine safetyVAERD
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