Evidence map›Paper›PMID 35952642›Full record

ArticleCell host & microbe2022

Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections.

Arnold M Salazar, Michael L Neugent, Nicole J De Nisco, Indira U Mysorekar

Open access · greenAbstract read
In one paragraph

Article in Cell host & microbe, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  11. AreVirulence · 2025
    Article
  12. Article
  13. Article
  14. Understanding the intricate interactions between microbiota and host.World journal of experimental medicine · 2025
    Review
  15. UropathogenicMicroorganisms · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Arnold M SalazarDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA.
Michael L NeugentDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Nicole J De NiscoDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA; Department of Urology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Indira U MysorekarDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center of Aging, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: indira.mysorekar@bcm.edu.
Baylor College of Medicine · USThe University of Texas at Dallas · US

Funding

INTERLEUKIN-6 AND AGING: IMPACT ON IMMUNE DEFENSE AND TISSUE REPAIR IN URINARY BLADDERR01AG052494 · NIA · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, MYSOREKAR, INDIRA U · 2016 to 2020
$1.6M
Defining the dynamics of urobiome structure and function in postmenopausal women and its role in recurrent UTI susceptibilityR01DK131267 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI DE NISCO, NICOLE JANELL · 2021 to 2025
$1.5M
Mechanism of age-associated inflammation and lymphoid neogenesis in the urinary bladderR56AG064634 · NIA · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, MYSOREKAR, INDIRA U · 2019 to 2019
$625k
Molecular and neuro-inflammatory biology of aging bladder in normal and disease states: ProjectP20DK119840 · NIDDK · WASHINGTON UNIVERSITY · PI MYSOREKAR, INDIRA U · 2018 to 2019
$612k
NIA NIH HHS R01 AG052494NIA NIH HHS R56 AG064634NIDDK NIH HHS P20 DK119840NIDDK NIH HHS R01 DK131267
6 · The paper itself

Abstract

The gut microbiome is a critical modulator of systemic physiology, including infectious disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli, knowledge of its role in urinary tract infections (UTIs) is limited. We discuss two recent studies, Thänert et al. (2022) and Worby et al. (2022), that interrogate the roles of the gut-bladder axis in UTIs.

Indexed as

Escherichia coli InfectionsUrinary Tract InfectionsUropathogenic Escherichia coliHumansUrinary Bladder

Identifiers

PMID35952642
PMCPMC9518703
OpenAlexW4291736454

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.