Evidence map›Paper›PMID 35952343›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Therapeutic effects of a soluble guanylate cyclase activator, BAY 60-2770, on lower urinary tract dysfunction in mice with spinal cord injury.

Daisuke Gotoh, Tetsuichi Saito, Sergei Karnup, Yosuke Morizawa, Shunta Hori, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Kiyohide Fujimoto, Naoki Yoshimura

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Construction of a prediction model for prognosis of bladder cancer based on the expression of ion channel-related genes.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Daisuke GotohDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-6056-3820
Tetsuichi SaitoDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Sergei KarnupDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yosuke MorizawaDepartment of Urology, Nara Medical University, Kashihara, Japan.
Shunta HoriDepartment of Urology, Nara Medical University, Kashihara, Japan.
Yasushi NakaiDepartment of Urology, Nara Medical University, Kashihara, Japan.
Makito MiyakeDepartment of Urology, Nara Medical University, Kashihara, Japan.
Kazumasa TorimotoDepartment of Urology, Nara Medical University, Kashihara, Japan.
Kiyohide FujimotoDepartment of Urology, Nara Medical University, Kashihara, Japan.
Naoki YoshimuraDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0001-8070-1664
Nara Medical University · JPUniversity of Pittsburgh · US

Funding

Intraspinal circuits supporting synergy between the bladder and urethral sphincter in miceR01DK129194 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KARNUP, SERGEI V, YOSHIMURA, NAOKI · 2021 to 2024
$1.4M
NIDDK NIH HHS R01 DK129194
6 · The paper itself

Abstract

We aimed to evaluate the effects of a soluble guanylate cyclase (sGC) activator, BAY 60-2770, on neurogenic lower urinary tract dysfunction in mice with spinal cord injury (SCI). Mice were divided into the following three groups: spinal cord intact (

Indexed as

Spinal Cord InjuriesUrinary BladderAnimalsBenzoatesBiphenyl CompoundsHydrocarbons, FluorinatedMiceNitric Oxide SynthaseRNA, MessengerSoluble Guanylyl Cyclase4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acidBenzoatesBiphenyl CompoundsHydrocarbons, FluorinatedNitric Oxide SynthaseRNA, MessengerSoluble Guanylyl Cyclasedetrusor overactivitymicesoluble guanylate cyclasespinal cord injuryurodynamics

Identifiers

PMID35952343
PMCPMC9485004
OpenAlexW4293282249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.