Evidence map›Paper›PMID 35951966›Full record

ArticleOrganic letters2022

Ring Opening of Aziridines by Pendant Silanols Allows for Preparations of (±)-Clavaminol H, (±)-Des-Acetyl-Clavaminol H, (±)-Dihydrosphingosine, and (±)-

Someshwar Nagamalla, Debobrata Paul, Joel T Mague, Shyam Sathyamoorthi

Erratum issuedAbstract read
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Ring-Opening of Aziridines Using Tethered Hemiketals.The Journal of organic chemistry · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Large-Scale Syntheses of Silanoxy-TetrahydrofuransOrganic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Someshwar NagamallaDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
Debobrata PaulDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0002-5270-7177
Joel T MagueDepartment of Chemistry, Tulane University, New Orleans, Louisiana 70118, United States.
Shyam SathyamoorthiDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0003-4705-7349

Funding

Tethered aza-Wacker Technology for Complex Antibiotic AssemblyR35GM142499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SATHYAMOORTHI, SHYAM · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM142499
6 · The paper itself

Abstract

We present a unique strategy for the synthesis of vicinal amino alcohols. Ring opening of aziridines with pendant silanols is compatible with a range of substrates. To engage productively in ring opening, the aziridine must be at least mildly activated, and a variety of such

Indexed as

AziridinesCeramidesMolecular StructureSilanesSphingosineStereoisomerismAziridinesCeramidesclavaminol HN-hexanoyldihydrosphingosinesafingolSilanessilanolSphingosine

Identifiers

PMID35951966
PMCPMC10017055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.