Evidence map›Paper›PMID 35951651›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Neuronal splicing regulator RBFOX3 mediates seizures via regulating

De-Fong Huang, Chih-Yu Lee, Ming-Yi Chou, Tzu-Yin Yang, Xuhui Cao, Yu-Hsuan Hsiao, Rui-Ni Wu, Cheng-Chang Lien, Yi-Shuian Huang, Hsiang-Po Huang and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  7. Characterization of theFASEB bioAdvances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

De-Fong HuangGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0003-0289-3650
Chih-Yu LeeGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Ming-Yi ChouGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0003-0685-0535
Tzu-Yin YangGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Xuhui CaoGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Yu-Hsuan HsiaoGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Rui-Ni WuGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0002-0823-9388
Cheng-Chang LienInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Yi-Shuian HuangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Hsiang-Po HuangGraduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0002-3382-305X
Susan Shur-Fen GauGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Hsien-Sung HuangGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0003-2657-3635
National Taiwan University · TWInstitute of Biomedical Sciences, Academia Sinica · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a common neurological disorder, which has been linked to mutations or deletions of RNA binding protein, fox-1 homolog (

Indexed as

DNA-Binding ProteinsGABAergic NeuronsNerve Tissue ProteinsNeuropeptide YSeizuresVesicle-Associated Membrane Protein 1AnimalsBumetanideDentate GyrusGABA Antagonistsgamma-Aminobutyric AcidGene DeletionMiceBumetanideDNA-Binding ProteinsGABA Antagonistsgamma-Aminobutyric AcidNerve Tissue ProteinsNeuN protein, mouseNeuropeptide YVesicle-Associated Membrane Protein 1vesicle-associated membrane protein 1, mouseGABAergic neuronsNPYRBFOX3SeizureVAMP1

Identifiers

PMID35951651
PMCPMC9388145
OpenAlexW4291009246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.