ArticlePloS one2022
Preliminary brain-behavioral neural correlates of anterior cruciate ligament injury risk landing biomechanics using a novel bilateral leg press neuroimaging paradigm.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Neural activity differences and their functional and clinical correlates after anterior cruciate ligament reconstruction: A systematic review of task-based fMRI studies.Experimental brain research · 2026Pooled it
- Distinct Movement-Related Cortical Control Following Anterior Cruciate Ligament Injury: A Scoping Review.Sports medicine - open · 2026Review
- Next-generation strategies for anterior cruciate ligament repair: constructing biointelligent ligament grafts integrating biomimetic design, immune modulation, and sensory feedback.Frontiers in bioengineering and biotechnology · 2026Review
- Effects of Visual Perturbation on Single-Leg Drop Jump Biomechanics in Patients Post-Anterior Cruciate Ligament Reconstruction.Journal of clinical medicine · 2025Article
- Magnetic resonance imaging of cruciate ligament disorders: current updates.EFORT open reviews · 2025Review
- Reliability of Brain Activity During a Supine Bilateral Leg Press and Association With Concurrent 3D Knee Joint Biomechanics.The European journal of neuroscience · 2025Article
- Neurophysiology of ACL Injury.Orthopedic reviews · 2025Article
- Sustainable performance plan development to prevent non-contact ACL injuries in youth and adolescent athletes: a clinical practice review.Annals of joint · 2025Review
- Differential neural mechanisms for movement adaptations following neuromuscular training in young female athletes with a history of sports-related concussion.Neuroscience · 2024Article
- High magnitude exposure to repetitive head impacts alters female adolescent brain activity for lower extremity motor control.Brain research · 2024Article
- The Evolution of Neuroimaging Technologies to Evaluate Neural Activity Related to Knee Pain and Injury Risk.Current reviews in musculoskeletal medicine · 2024Review
- Neurocognitive & Ecological Motor Learning Considerations for the 11+ ACL Injury Prevention Program: A Commentary.International journal of sports physical therapy · 2024Article
- The Impact of Visual Perturbation Neuromuscular Training on Landing Mechanics and Neural Activity: A Pilot Study.International journal of sports physical therapy · 2024Article
- Task-Driven Neurophysiological qEEG Baseline Performance Capabilities in Healthy, Uninjured Division-I College Athletes.International journal of sports physical therapy · 2024Article
- The effects of sports-related concussion history on female adolescent brain activity and connectivity for bilateral lower extremity knee motor control.Psychophysiology · 2023Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Anterior cruciate ligament (ACL) injury risk reduction strategies primarily focus on biomechanical factors related to frontal plane knee motion and loading. Although central nervous system processing has emerged as a contributor to injury risk, brain activity associated with the resultant ACL injury-risk biomechanics is limited. Thus, the purposes of this preliminary study were to determine the relationship between bilateral motor control brain activity and injury risk biomechanics and isolate differences in brain activity for those who demonstrate high versus low ACL injury risk. Thirty-one high school female athletes completed a novel, multi-joint leg press during brain functional magnetic resonance imaging (fMRI) to characterize bilateral motor control brain activity. Athletes also completed an established biomechanical assessment of ACL injury risk biomechanics within a 3D motion analysis laboratory. Knee abduction moments during landing were modelled as a covariate of interest within the fMRI analyses to identify directional relationships with brain activity and an injury-risk group classification analysis, based on established knee abduction moment cut-points. Greater landing knee abduction moments were associated with greater lingual gyrus, intracalcarine cortex, posterior cingulate cortex and precuneus activity when performing the bilateral leg press (all z > 3.1, p < .05; multiple comparison corrected). In the follow-up injury-risk classification analysis, those classified as high ACL injury-risk had greater activity in the lingual gyrus, parietal cortex and bilateral primary and secondary motor cortices relative to those classified as low ACL injury-risk (all z > 3.1, p < .05; multiple comparison corrected). In young female athletes, elevated brain activity for bilateral leg motor control in regions that integrate sensory, spatial, and attentional information were related to ACL injury-risk landing biomechanics. These data implicate crossmodal visual and proprioceptive integration brain activity and knee spatial awareness as potential neurotherapeutic targets to optimize ACL injury-risk reduction strategies.
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Registered trials
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