Evidence map›Paper›PMID 35951526›Full record

ArticlePLoS computational biology2022

Ten quick tips for biomarker discovery and validation analyses using machine learning.

Ramon Diaz-Uriarte, Elisa Gómez de Lope, Rosalba Giugno, Holger Fröhlich, Petr V Nazarov, Isabel A Nepomuceno-Chamorro, Armin Rauschenberger, Enrico Glaab

Open access · goldAbstract read
In one paragraph

Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Pathway Analysis Interpretation in the Multi-Omic Era.Biotech (Basel (Switzerland)) · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Ramon Diaz-UriarteDepartment of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas 'Alberto Sols' (UAM-CSIC), Madrid, Spain.ORCID 0000-0002-6637-9039
Elisa Gómez de LopeLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg.ORCID 0000-0002-7115-7393
Rosalba GiugnoDepartment of Computer Science, University of Verona, Verona, Italy.
Holger FröhlichDepartment of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin, Germany.ORCID 0000-0002-5328-1243
Petr V NazarovDepartment of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg.ORCID 0000-0003-3443-0298
Isabel A Nepomuceno-ChamorroDpto. de Lenguajes y Sistemas Informáticos, University of Seville, Seville, Spain.
Armin RauschenbergerLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg.ORCID 0000-0001-6498-4801
Enrico GlaabLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg.ORCID 0000-0003-3977-7469
University of Luxembourg · LUInstituto de Investigaciones Biomédicas Sols-Morreale · ESLuxembourg Institute of Health · LUUniversidad de Sevilla · ESUniversity of Bonn · DEUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomedical ResearchMachine LearningBiomarkersComputational BiologyBiomarkers

Identifiers

PMID35951526
PMCPMC9371329
OpenAlexW4290973528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.