Evidence map›Paper›PMID 35951299›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival.

Florent Busi, Florian Turbant, Jehan Waeytens, Omar El Hamoui, Frank Wien, Véronique Arluison

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Interactions and Insertion ofInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Florent BusiUniversité Paris Cité, BFA, UMR 8251, CNRS, Paris, France. florent.busi@u-paris.fr.
Florian TurbantLaboratoire Léon Brillouin LLB, CEA, CNRS UMR 12, Université Paris Saclay, CEA Saclay, Gif-sur-Yvette, France.
Jehan WaeytensStructure et Fonction des Membranes Biologiques, Université libre de Bruxelles, Bruxelles, Belgium.
Omar El HamouiDISCO Beamline, Synchrotron SOLEIL, L'Orme des Merisiers Saint Aubin, Gif-sur-Yvette, France.
Frank WienDISCO Beamline, Synchrotron SOLEIL, L'Orme des Merisiers Saint Aubin, Gif-sur-Yvette, France.
Véronique ArluisonUniversité Paris Cité, Paris, France.
Synchrotron soleil · FRCentre National de la Recherche Scientifique · FRLaboratoire Léon Brillouin · FRUniversité Libre de Bruxelles · BEUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid inhibitors, such as the green tea compound epigallocatechin gallate EGCG, apomorphine or curlicide, have antibacterial properties. Conversely, antibiotics such as tetracycline derivatives or rifampicin also affect eukaryotic amyloids formation and may be used to treat neurodegenerative diseases. This opens the possibility for existing drugs to be repurposed in view of new therapy, targeting amyloid-like proteins from eukaryotes to prokaryotes and conversely. Here we present how to evaluate the effect of these amyloid-forming inhibitors on bacterial amyloid self-assemblies in vitro and on bacterial survival. The different approaches possible are presented.

Indexed as

AmyloidosisCatechinAmyloidAmyloidogenic ProteinsAnti-Bacterial AgentsBacteriaHumansAmyloidAmyloidogenic ProteinsAnti-Bacterial AgentsCatechinAntibacterialBacterial adaptationBacterial amyloidFunctional amyloidHfqProtein fibrillation inhibitionProtein fibrils

Identifiers

PMID35951299
OpenAlexW4291019362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.