Evidence map›Paper›PMID 35951131›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Early predictive factors for progression to kidney failure in infants with severe congenital anomalies of the kidney and urinary tract.

Kentaro Nishi, Osamu Uemura, Ryoko Harada, Masaki Yamamoto, Yusuke Okuda, Kenichiro Miura, Yoshimitsu Gotoh, Tomoo Kise, Daishi Hirano, Yuko Hamasaki and 9 more

Abstract read
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Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

Kentaro NishiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Osamu UemuraIchinomiya Medical Treatment and Habilitation Center, Aichi, Japan.
Ryoko HaradaDepartment of Nephrology and Rheumatology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Masaki YamamotoDepartment of Pediatrics, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Yusuke OkudaDepartment of Pediatrics, Kitasato University School of Medicine, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Kenichiro MiuraDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Yoshimitsu GotohDepartment of Pediatric Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Aichi, Japan.
Tomoo KiseDepartment of Pediatric Nephrology, Okinawa Prefectural Nanbu Medical Center, Children's Medical Center, Okinawa, Japan.
Daishi HiranoDepartment of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan.
Yuko HamasakiDepartment of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
Naoya FujitaDepartment of Nephrology, Aichi Children's Health and Medical Center, Aichi, Japan.
Toru UchimuraDepartment of Pediatrics, Yokohama City University Medical Center, Kanagawa, Japan.
Takeshi NinchojiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Hyogo, Japan.
Tetsuya IsayamaDivision of Neonatology, Center of Maternal-Fetal Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Riku HamadaDepartment of Nephrology and Rheumatology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Koichi KameiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Tetsuji KanekoClinical Research Support Center, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Kenji IshikuraDepartment of Pediatrics, Kitasato University School of Medicine, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan. k-ishikura@umin.ac.jp.ORCID 0000-0003-2692-6437
Pediatric CKD Study Group in Japan in conjunction with the Committee of Measures for Pediatric CKD of the Japanese Society of Pediatric Nephrology
National Center For Child Health and Development · JPTokyo Metropolitan Children's Medical Center · JPKitasato University · JPIchinomiya Kenshin College · JPJapanese Red Cross Nagoya Daini Hospital · JPJikei University School of Medicine · JPKobe University · JPSeirei Hamamatsu General Hospital · JPToho University · JPTokyo Women's Medical University · JPYokohama City University Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere congenital anomalies of the kidney and urinary tract (CAKUT) progress to infantile kidney failure with replacement therapy (KFRT). Although prompt and precise prediction of kidney outcomes is important, early predictive factors for its progression remain incompletely defined.

methodsThis retrospective cohort study included patients with CAKUT treated at 12 centers between 2009 and 2020. Patients with a maximum serum creatinine level ≤ 1.0 mg/dL during the first 3 days, patients who died of respiratory failure during the neonatal period, patients who progressed to KFRT within the first 3 days, and patients lacking sufficient data were excluded.

resultsOf 2187 patients with CAKUT, 92 were finally analyzed. Twenty-five patients (27%) progressed to KFRT and 24 (26%) had stage 3-5 chronic kidney disease without replacement therapy during the median observation period of 52.0 (interquartile range, 22.0-87.8) months. Among these, 22 (24%) progressed to infantile KFRT. The kidney survival rate during the infantile period was significantly lower in patients with a maximum serum creatinine level during the first 3 days (Cr-day3-max) ≥ 2.5 mg/dL (21.8%) compared with those with a Cr-day3-max < 2.5 mg/dL (95.2%) (log-rank, P < 0.001). Multivariate analysis demonstrated Cr-day3-max (P < 0.001) and oligohydramnios (P = 0.025) were associated with higher risk of infantile KFRT. Eighty-two patients (89%) were alive at the last follow-up.

conclusionsNeonatal kidney function, including Cr-day3-max, was associated with kidney outcomes in patients with severe CAKUT. Aggressive therapy for severe CAKUT may have good long-term life outcomes through infantile dialysis and kidney transplantation. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Renal Insufficiency, ChronicUrinary TractCreatinineFemaleHumansInfantInfant, NewbornKidneyPregnancyRenal DialysisRetrospective StudiesUrogenital AbnormalitiesVesico-Ureteral RefluxCreatinineChildrenChronic kidney diseaseCongenital anomalies of the kidney and urinary tractDialysisInfantsKidney transplantation

Identifiers

PMID35951131
OpenAlexW4291019064

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.