Evidence map›Paper›PMID 35951113›Full record

Trial reportEuropean archives of psychiatry and clinical neuroscience2023

Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation.

Haejin Hong, Rye Young Kim, Yumi Song, Chaewon Suh, Hyangwon Lee, In Kyoon Lyoo, Sujung Yoon, Soo Mee Lim, Suji Lee

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of psychiatry and clinical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02932085 (Pilot Study for the Effects of Transcranial Magnetic Stimulation on the Brain Using an Electronic Medical Device), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02932085 nacompletednot on this map

Pilot Study for the Effects of Transcranial Magnetic Stimulation on the Brain Using an Electronic Medical Device: A Single Institution, Randomized, Double-blind, Sham-controlled Study Using Multimodal Neuroimaging in Healthy Young Adults

TypeinterventionalSponsorEwha Womans University Mokdong HospitalRan2016 to 2017Enrolled30ConditionsHealthyArmsNeurostar TMS Therapy System, NeuroStar XPLOR System
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Haejin Hong *Ewha Brain Institute, Ewha W. University, Seoul, South Korea.
Rye Young Kim *Ewha Brain Institute, Ewha W. University, Seoul, South Korea.
Yumi SongEwha Brain Institute, Ewha W. University, Seoul, South Korea.
Chaewon SuhEwha Brain Institute, Ewha W. University, Seoul, South Korea.
Hyangwon LeeEwha Brain Institute, Ewha W. University, Seoul, South Korea.
In Kyoon LyooEwha Brain Institute, Ewha W. University, Seoul, South Korea.
Sujung YoonEwha Brain Institute, Ewha W. University, Seoul, South Korea.
Soo Mee Lim *Department of Radiology, Ewha W. University College of Medicine, Seoul, South Korea. soomee@ewha.ac.kr.
Suji Lee *Ewha Brain Institute, Ewha W. University, Seoul, South Korea. sujillee@ewha.ac.kr.ORCID http://orcid.org/0000-0003-1843-4598
Ewha Womans University · KR

Funding

National Research Foundation of Korea 2019R1A2C1089515National Research Foundation of Korea 2020M3E5D9080555National Research Foundation of Korea 2020R1A6A1A03043528
6 · The paper itself

Abstract

Research integrating molecular and imaging data provides important insights into how the genetic profile associated with dopamine signaling influences inter-individual differences in brain functions. However, the effects of genetic variations in dopamine signaling on the heterogeneity of brain changes induced by repetitive transcranial magnetic stimulation (rTMS) still remain unclear. The current study examined the composite effects of genetic variations in dopamine-related genes on rTMS-induced brain responses in terms of the functional network connectivity and working memory performance. Healthy individuals (n = 30) participated in a randomized, double-blind, sham-controlled study with a crossover design of five consecutive days where active rTMS or sham stimulation sessions were administered over the left dorsolateral prefrontal cortex (DLPFC) of the brain. Participants were mostly women (n = 29) and genotyped for polymorphisms in the catechol-O-methyltransferase and D2 dopamine receptor genes and categorized according to their genetic composite scores: high vs. low dopamine signaling groups. Pre- and post-intervention data of resting-state functional magnetic resonance imaging and working memory performance were obtained from 27 individuals with active rTMS and 30 with sham stimulation sessions. The mean functional connectivity within the resting-state networks centered on the DLPFC increased in the high dopamine signaling group. Working memory performance also improved with rTMS in the high dopamine signaling group compared to that in the low dopamine signaling group. The present results suggest that genetic predisposition to higher dopamine signaling may be a promising neurobiological predictor for rTMS effects on cognitive enhancement.Trial registration: ClinicalTrials.gov (NCT02932085).

Indexed as

Catechol O-MethyltransferaseTranscranial Magnetic StimulationBrainDopamineFemaleGenetic ProfileHumansMagnetic Resonance ImagingMalePrefrontal CortexCatechol O-MethyltransferaseDopamineDopamineFunctional connectivityGenetic polymorphismRepetitive transcranial magnetic stimulationResting-state networkWorking memory performance

Identifiers

PMID35951113
OpenAlexW4291021149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.