Evidence map›Paper›PMID 35950843›Full record

ArticleAntimicrobial agents and chemotherapy2022

A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140.

Nachimuthu Ramesh, Prasanth Manohar, Kandasamy Eniyan, Loganathan Archana, Sudarsanan Athira, Belinda Loh, Long Ma, Sebastian Leptihn

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Isolation and identification of a novel phage targeting clinical multidrug-resistantFrontiers in cellular and infection microbiology · 2024
    Article
  10. Article
  11. Characterization of the LysP2110-HolP2110 Lysis System inInternational journal of molecular sciences · 2023
    Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Nachimuthu RameshAntibiotic Resistance and Phage Therapy Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.ORCID 0000-0002-8350-1809
Prasanth ManoharZhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, Zhejiang, People's Republic of China.ORCID 0000-0002-5546-1117
Kandasamy EniyanAntibiotic Resistance and Phage Therapy Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Loganathan ArchanaAntibiotic Resistance and Phage Therapy Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Sudarsanan AthiraAntibiotic Resistance and Phage Therapy Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Belinda LohFraunhofer Institute for Cell Therapy and Immunology (IZI), Department of Antimicrobial Biotechnology, Leipzig, Germany.ORCID 0000-0003-1364-6911
Long MaZhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, Zhejiang, People's Republic of China.
Sebastian LeptihnZhejiang University-University of Edinburgh (ZJU-UoE) Institute, Zhejiang University, Haining, Zhejiang, People's Republic of China.ORCID 0000-0002-4847-4622
Vellore Institute of Technology University · INZhejiang University-University of Edinburgh Institute · CNFraunhofer Institute for Cell Therapy and Immunology · DESir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteriophages and bacteriophage-derived peptidoglycan hydrolases (endolysins) present promising alternatives for the treatment of infections caused by multidrug resistant Gram-negative and Gram-positive pathogens. In this study, Gp105, a putative lysozyme murein hydrolase from Enterobacter phage myPSH1140 was characterized

Indexed as

BacteriophagesN-Acetylmuramoyl-L-alanine AmidaseAnti-Bacterial AgentsEndopeptidasesEnterobacterGlycoside HydrolasesKlebsiella pneumoniaeMuramidaseMyoviridaePeptidoglycanPseudomonas aeruginosaAnti-Bacterial AgentsEndopeptidasesGlycoside HydrolasesMuramidaseN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanantimicrobial proteinsendolysinsGram-negative pathogenspeptidoglycan hydrolasephage therapy

Identifiers

PMID35950843
PMCPMC9487488
OpenAlexW4290804136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.