ArticleInternational endodontic journal2022
Cytocompatibility and bioactive potential of AH Plus Bioceramic Sealer: An in vitro study.
Article in International endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Pooled it
- Endodontic treatment outcomes in apical periodontitis cases by the lateral condensation versus warm vertical compaction techniques: a one-year follow-up study.BMC oral health · 2026Trial
- Evaluation of the physicochemical properties and adhesive interface quality of BioRoot Flow and BioRoot RCS endodontic sealers: An in vitro study.Clinical oral investigations · 2026Article
- Fatigue behaviour of root filled teeth: The role of endodontic sealers and restorative techniques.European journal of oral sciences · 2026Article
- Detecting Residual Root Canal Filling Material After Retreatment: Cone-Beam Computed Tomography and Digital Microscopy Compared with Microcomputed Tomography.Dentistry journal · 2026Article
- Single cone versus carrier-based obturation using a premixed bioceramic sealer in postgraduate master cohort: a 36 months retrospective evaluation.Clinical oral investigations · 2026Article
- Setting Characteristics, Solubility, Bioactivity and Interaction with Dentin of Four Calcium Silicate-Based Endodontic Sealers.Journal of functional biomaterials · 2026Article
- Effect of Pre-Setting Exposure to 17% EDTA on Physicochemical and Surface Properties of AH Plus Bioceramic and AH Plus Endodontic Sealers.Dentistry journal · 2026Article
- Retreatment of Two Bioceramic Sealers Included Two Different Percentages of Calcium Silicate Using Two Endodontic File Systems: An In Vitro Study.European journal of dentistry · 2026Article
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Article
- Short-term histopathological effects of direct peripheral nerve exposure to AH Plus® Bioceramic Sealer in rats: an exploratory assessment of Stemregen® supplementation.Biomaterial investigations in dentistry · 2026Article
- Percentage of Gutta-Percha-Filled Areas in Canals Obturated by Two Different Core Techniques with Endodontic Bioceramics Sealer.Materials (Basel, Switzerland) · 2025Article
- Osteogenic Potential of Various Premixed Hydraulic Calcium Silicate-Based Sealers on Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2025Article
- The effect of four calcium silicate-based sealers and sealer extrusion on postoperative pain: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2025Article
- Effect of different taper values and bioceramic sealer forms on fracture resistance of mandibular premolars prepared with single-file Ni-Ti systems: an in vitro study.BMC oral health · 2025Article
- In Vitro Bioactivity and Cytotoxicity Assessment of Two Root Canal Sealers.Materials (Basel, Switzerland) · 2025Article
- Resistance of gutta-percha and calcium silicate-based sealer to dislocation after non-surgical root canal retreatment.BMC oral health · 2025Article
- Biocompatibility and Bioactivity Evaluation of Novel Calcium Silicate-Based Sealer: In Vitro Study on Human Dental Pulp Stem Cells.European journal of dentistry · 2025Article
- Cytotoxicity and genotoxicity evaluation of AH Plus, Well-Root ST, and AH Plus Bioceramic Sealer.BMC oral health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo assess the cytocompatibility and bioactive potential of the new calcium silicate cement-based sealer AH Plus Bioceramic Sealer (AHPbcs) on human periodontal ligament stem cells (hPDLSCs) compared with the epoxy resin-based sealer AH Plus (AHP) and the calcium silicate cement-based sealer Endosequence BC Sealer (ESbcs). METHODOLOGY: Standardized sample discs and 1:1, 1:2 and 1:4 eluates of the tested materials were prepared. The following assays were performed: surface element distribution via SEM-EDX, cell attachment and morphology via SEM, cell viability via a MTT assay, cell migration/proliferation via a wound-healing assay, osteo/cemento/odontogenic marker expression via RT-qPCR and cell mineralized nodule formation via Alizarin Red S staining. HPDLSCs were isolated from extracted third molars. Comparisons were made with hPDLSCs cultured in unconditioned (negative control) or osteogenic (positive control) culture media. Statistical significance was established at p < .05.
resultsA higher peak of Ca
conclusionAH Plus Bioceramic Sealer exhibited a significantly higher cytocompatibility and bioactive potential than AH Plus and a similar cytocompatibility to that of Endosequence BC Sealer. Endosequence BC Sealer exhibited a significantly higher mineralization potential than the other tested sealers. The results from this in vitro study act as supporting evidence for the use of AH Plus Bioceramic Sealer in root canal treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.