Evidence map›Paper›PMID 35950755›Full record

ArticlemBio2022

Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes.

Suzanne E Hocking, Lindsay B Stewart, Aline Freville, Adam J Reid, Sarah J Tarr, Kevin K A Tetteh, Christian Flueck, Ambroise D Ahouidi, Alfred Amambua-Ngwa, Mahamadou Diakite and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Suzanne E HockingDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Lindsay B StewartDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Aline FrevilleDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Adam J ReidWellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Sarah J TarrDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Kevin K A TettehDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Christian FlueckDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ambroise D AhouidiLe Dantec Hospital, Université Cheikh Anta Diop, Dakar, Senegal.
Alfred Amambua-NgwaMRC Unit The Gambia at London School of Hygiene and Tropical Medicine (LSHTM), Fajara, Banjul, The Gambia.
Mahamadou DiakiteMalaria Research and Training Center, University of Bamako, Bamako, Mali.
Gordon A AwandareWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, University of Ghanagrid.8652.9, Legon, Ghana.
David J ConwayDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0002-8711-3037
London School of Hygiene & Tropical Medicine · GBCheikh Anta Diop University · SNMRC Unit the Gambia · GMUniversity of Bamako · MLUniversity of Ghana · GHWellcome Sanger Institute · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MC_PC_20037Medical Research Council MR/S009760/1Wellcome TrustWellcome Trust (WT) 206194/Z/17/Z
6 · The paper itself

Abstract

The merozoite surface protein MSPDBL2 of Plasmodium falciparum is under strong balancing selection and is a target of naturally acquired antibodies. Remarkably, MSPDBL2 is expressed in only a minority of mature schizonts of any cultured parasite line, and

Indexed as

Malaria, FalciparumParasitesAnimalsMembrane ProteinsMerozoitesPlasmodium falciparumProtozoan ProteinsSchizontsTranscriptomeMembrane ProteinsProtozoan Proteinsantigenic variationblood culturemalariasexual developmenttranscription

Identifiers

PMID35950755
PMCPMC9426457
OpenAlexW4290805740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.