Evidence map›Paper›PMID 35950677›Full record

ArticleMolecular pharmaceutics2022

Low-Frequency Vibrational Spectroscopy and Quantum Mechanical Simulations of the Crystalline Polymorphs of the Antiviral Drug Ribavirin.

Margaret P Davis, Timothy M Korter

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Compression of Ribavirin to 35 GPa.Crystal growth & design · 2026
    Article
  2. High-Pressure Polymorphism of Ribavirin.Crystal growth & design · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Margaret P DavisDepartment of Chemistry, Syracuse University, 1-133 Center for Science and Technology, Syracuse, New York 13244-4100, United States.ORCID 0000-0003-0191-064X
Timothy M KorterDepartment of Chemistry, Syracuse University, 1-133 Center for Science and Technology, Syracuse, New York 13244-4100, United States.ORCID 0000-0002-0398-5680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crystal polymorphism is a common phenomenon in pharmaceutical solids and a critical issue when considering the formulation of therapeutics since multiple polymorphs may form during drug manufacturing. Low-frequency vibrational spectroscopy is sensitive to polymorphic content, and in this work, terahertz time-domain spectroscopy and low-frequency Raman spectroscopy were utilized in the study of crystalline ribavirin, a widely applicable antiviral. Characteristic spectra with numerous peaks in the sub-200 cm

Indexed as

Terahertz SpectroscopyVibrationAntiviral AgentsCrystallizationPharmaceutical PreparationsRibavirinAntiviral AgentsPharmaceutical PreparationsRibavirincomputational chemistrycrystallographyfar-infrared spectroscopyperiodic boundary conditionsphase transition

Identifiers

PMID35950677
PMCPMC9449968

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.