Evidence map›Paper›PMID 35950645›Full record

ArticleEpilepsia open2025

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force.

Erwin A van Vliet, Michael S Hildebrand, James D Mills, Gary P Brennan, Tore Eid, Susan A Masino, Vicky Whittemore, Laura Bindila, Kevin K Wang, Manisha Patel and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erwin A van VlietCenter for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-5747-3202
Michael S HildebrandEpilepsy Research Centre, Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia.ORCID https://orcid.org/0000-0003-2739-0515
James D MillsAmsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Gary P BrennanUCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-4262-0481
Tore EidDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-9217-6393
Susan A MasinoNeuroscience Program and Psychology Department, Life Sciences Center, Trinity College, Hartford, Connecticut, USA.ORCID https://orcid.org/0000-0003-4237-4900
Vicky WhittemoreDivision of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-3980-9451
Laura BindilaClinical Lipidomics Unit, Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.ORCID https://orcid.org/0000-0001-5538-2008
Kevin K WangDepartment of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0002-9343-6473
Manisha PatelDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Piero PeruccaEpilepsy Research Centre, Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia.ORCID https://orcid.org/0000-0002-7855-7066
Christopher A ReidEpilepsy Research Centre, Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia.ORCID https://orcid.org/0000-0002-1457-8028

Funding

SUPEROXIDE RADICALS IN SEIZURE-INDUCED NEURONAL DEATHR01NS039587 · NINDS · UNIVERSITY OF COLORADO DENVER · PI PATEL, MANISHA N · 2000 to 2019
$5.9M
Redox Control of Seizure-Induced Neuroinflammation.R01NS086423 · NINDS · UNIVERSITY OF COLORADO DENVER · PI PATEL, MANISHA N · 2013 to 2022
$3.0M
NINDS NIH HHS R01 NS039587NINDS NIH HHS R01 NS086423
6 · The paper itself

Abstract

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research-related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics, and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics, and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two-part series of omics papers with the second installment to cover proteomics, lipidomics, and metabolomics in adult rodents.

Indexed as

Disease Models, AnimalEpigenomicsEpilepsyGenomicsTranscriptomeTranslational Research, BiomedicalAdvisory CommitteesAnimalsMiceRatscommon data elementsmouseomic data processingpreclinicalrat

Identifiers

PMID35950645
PMCPMC12375979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.