ArticleAnnals of the Royal College of Surgeons of England2023
Does titanium cage subsidence affect clinical outcomes in ACDF surgery? A tertiary centre experience.
Article in Annals of the Royal College of Surgeons of England, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of ACDF with stand-alone PEEK cage versus zero-p implant for the treatment of cervical degenerative disease: a systematic review and meta-analysis.Frontiers in surgery · 2026Pooled it
- Risk of subsidence following ACDF with the coalition™ (Globus Medical) cage: a multivariable analysis identifying preoperative radiculopathy as the primary risk factor.Acta neurochirurgica · 2026Article
- Stand-alone porous titanium cages for anterior cervical discectomy and fusion: clinical outcomes in a multicenter experience.Neurosurgical review · 2026Observational
- Comparison of Stand-Alone Cage versus Intervertebral Cage with Pedicle Screw and Rod Fixation in Dogs with Degenerative Lumbosacral Stenosis.Veterinary and comparative orthopaedics and traumatology : V.C.O.T · 2026Article
- Interbody cage subsidence after ACDF: a predictor of non-union and neck pain despite normal bone mineral density.Neurosurgical review · 2026Article
- Preoperative Alignment and Interbody Cage Design Influence Radiographic Outcomes Following Anterior Cervical Discectomy and Fusion.Journal of clinical medicine · 2026Article
- Impact of cage type on subsidence following anterior cervical discectomy and fusion: a retrospective study.Asian spine journal · 2026Article
- Plate Augmentation in The Prevention of 3D-Printed Tritanium Cage Subsidence Following Anterior Cervical Discectomy and Fusion: A Retrospective Cohort Study.The Iowa orthopaedic journal · 2026Article
- Deciphering subsidence risk after ACDF: a biomechanical study on bone density and endplate thickness.BMC musculoskeletal disorders · 2025Article
- Predictors of Implant Subsidence and Its Impact on Cervical Alignment Following Anterior Cervical Discectomy and Fusion: A Retrospective Study.Journal of clinical medicine · 2025Article
- Role of preoperative Hounsfield units in predicting subsidence after anterior cervical discectomy and fusion in the United States: a retrospective analysis including osteopenia diagnosis.Asian spine journal · 2025Article
- Predictive value of vertebral specificity of bone mineral density for cage subsidence among patients undergoing anterior cervical diskectomy and fusion: a retrospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Clinical and radiographic outcomes after index anterior cervical discectomy and fusion with interbody spacer with integrated anchor fixation: a single-surgeon case study.Journal of spine surgery (Hong Kong) · 2024Article
- Preliminary exploration of the biomechanical properties of three novel cervical porous fusion cages using a finite element study.BMC musculoskeletal disorders · 2023Article
- The Effect of Subsidence on Segmental and Global Lordosis at Long-term Follow-up After Anterior Cervical Discectomy and Fusion.Neurospine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCage subsidence after anterior cervical discectomy and fusion (ACDF) surgery has been well documented with rates of up to 40%. Cages fill the void after cervical discectomy and promote fusion. These materials have different biomechanical profiles with differing rates of subsidence. This retrospective cohort study aimed to determine subsidence rates specifically associated with the novel Emerging Implant Technologies (EIT) titanium cage, identify risk factors associated with subsidence, and evaluate whether subsidence affects clinical outcomes.
methodsACDF with insertion of stand-alone EIT cage was performed in 39 patients (64 levels) between December 2016 and February 2019 with a median follow-up of 11 months. Patients were classified into two groups; subsidence and non-subsidence, and were compared in terms of the resultant clinical outcomes as well as presence of risk factors. Health-related quality of life (HRQOL) outcomes were assessed using Visual Analogue Scale (VAS) for neck and arm pain, EuroQol 5-Dimension 5-Level (EQ-5D-5L), EuroQol Visual Analogue Scale (EQ VAS) and Neck Disability Index (NDI) scores.
resultsCage subsidence (>3mm) was present in nine patients (23%), which corresponded to ten levels treated (16%). Development of subsidence was not associated with gender (
conclusionsThe EIT cage seems to be associated with lower rates of subsidence compared with other cage types. Cage subsidence was not associated with HRQOL outcomes or risk factors.
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