Evidence map›Paper›PMID 35950455›Full record

ArticleMolecules and cells2022

Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression.

Chang Man Ha, Dong Hee Kim, Tae Hwan Lee, Han Rae Kim, Jungil Choi, Yoonju Kim, Dasol Kang, Jeong Woo Park, Sergio R Ojeda, Jin Kwon Jeong and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Chang Man HaBrain Research Core Facilities and Global Relation Center of Research Strategy Office, Korea Brain Research Institute, Daegu 41068, Korea.ORCID https://orcid.org/0000-0002-6734-6597
Dong Hee KimDepartment of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.ORCID https://orcid.org/0000-0003-4422-2468
Tae Hwan LeeDepartment of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.ORCID https://orcid.org/0000-0001-6259-4682
Han Rae KimDepartment of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.ORCID https://orcid.org/0000-0002-9108-2421
Jungil ChoiBioenvironmental Science & Technology Division, Korea Institute of Toxicology, Jinju 52834, Korea.ORCID https://orcid.org/0000-0001-6490-0292
Yoonju KimBrain Research Core Facilities and Global Relation Center of Research Strategy Office, Korea Brain Research Institute, Daegu 41068, Korea.ORCID https://orcid.org/0000-0003-2657-2923
Dasol KangDepartment of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.ORCID https://orcid.org/0000-0002-3628-8582
Jeong Woo ParkDepartment of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.ORCID https://orcid.org/0000-0002-3355-6908
Sergio R OjedaDivision of Neuroscience, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR 97006, USA.ORCID https://orcid.org/0000-0001-6216-8990
Jin Kwon JeongDepartment of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.ORCID https://orcid.org/0000-0002-5261-4915
Byung Ju LeeDepartment of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.ORCID https://orcid.org/0000-0001-5519-8884
University of Ulsan · KRGeorge Washington University · USKorea Brain Research Institute · KRKorea Institute of Toxicology · KROregon National Primate Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preproenkephalin (PPE) is a precursor molecule for multiple endogenous opioid peptides Leu-enkephalin (ENK) and Met-ENK, which are involved in a wide variety of modulatory functions in the nervous system. Despite the functional importance of ENK in the brain, the effect of brain-derived factor(s) on PPE expression is unknown. We report the dual effect of neural epidermal growth factor (EGF)-likelike 2 (NELL2) on PPE gene expression. In cultured NIH3T3 cells, transfection of NELL2 expression vectors induced an inhibition of PPE transcription intracellularly, in parallel with downregulation of protein kinase C signaling pathways and extracellular signal-regulated kinase. Interestingly, these phenomena were reversed when synthetic NELL2 was administered extracellularly. The

Indexed as

Epidermal Growth FactorNerve Tissue ProteinsAnimalsEnkephalinsGene ExpressionMiceNIH 3T3 CellsProtein PrecursorsRatsEnkephalinsEpidermal Growth FactorNell2 protein, ratNerve Tissue ProteinspreproenkephalinProtein Precursorscalcium ionendoplasmic reticulumextracellular signal-regulated kinaseNELL2preproenkephalinprotein kinase C

Identifiers

PMID35950455
PMCPMC9385569
OpenAlexW4291014800

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.