Evidence map›Paper›PMID 35950184›Full record

ArticleComputational and structural biotechnology journal2022

A combined metabolomics and molecular biology approach to reveal hepatic injury and underlying mechanisms after chronic l-lactate exposure in mice.

Minjian Dong, Qingqing Yi, Danjie Shen, Jiapin Yan, Haowei Jiang, Jiaojiao Xie, Liangcai Zhao, Hongchang Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Minjian DongSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Qingqing YiSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Danjie ShenSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Jiapin YanSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Haowei JiangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Jiaojiao XieSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Liangcai ZhaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Hongchang GaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to explore whether chronic l-lactate exposure could affect the peripheral tissues of mice and to determine the underlying pathogenesis. Herein, male C57BL/6 mice were divided into control and l-lactate groups. After l-lactate treatment for eight weeks (1 g/kg), metabolic changes in liver, kidney, muscle, and serum samples were determined by

Indexed as

AD, Alzheimer's diseaseALT, alanine aminotransferaseAST, aspartate aminotransferaseBDNF, brain-derived neurotrophic factorBUN, blood urea nitrogenCREB, cyclic AMP-responsive element binding proteinCyp2e1, cytochrome P450 2E1DHE, dihydroethidiumGclc, c-glutamylcysteine ligase catalytic subunitGSH, glutathioneH&E, hematoxylin and eosinHepatic injuryLDH, lactate dehydrogenasel-lactateMCT, monocarboxylate transporterMDA, malondialdehydeMetabolomicsNMR, nuclear magnetic resonanceNox2, NADPH oxidase-2Nuclear magnetic resonanceOPLS-DA, orthogonal projection to latent structures discriminant analysisPAS, periodic acid-SchiffROS, reactive oxygen speciesSCR, serum creatinineSirt1, silent information regulator 1Sod2, superoxide dismutase-2TCA, tricarboxylic acidTSP, trimethylsilyl propionateVIP, variable importance in projectionVLDL/LDL, very low-density lipoproteins/low-density lipoproteins

Identifiers

PMID35950184
PMCPMC9352416
OpenAlexW4287448215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.