Evidence map›Paper›PMID 35949945›Full record

ArticleJournal of medical cases2022

Acute Interstitial Nephritis Induced by Clozapine.

Praveena Vantipalli, Sasmit Roy, Narayana M Koduri, Venu Madhav Konala, Amarinder Singh Garcha, Srikanth Kunaparaju, Raul Ayala, Samanvitha Sai Yarram, Sreedhar Adapa

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical cases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Praveena VantipalliDepartment of Family Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Sasmit RoyDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Narayana M KoduriDepartment of Psychiatry, Great Plains Health, North Platte, NE, USA.
Venu Madhav KonalaDepartment of Internal Medicine, Precision Cancer Center, Ashland, KY, USA.
Amarinder Singh GarchaDepartment of Internal Medicine, Adventist Health, Hanford, CA, USA.
Srikanth KunaparajuRichmond Nephrology Associates, Richmond, VA, USA.
Raul AyalaDepartment of Family Medicine, Adventist Health, Hanford, CA, USA.
Samanvitha Sai YarramGeneral Medicine, The University of New England Joint Medical Program, Armidale, New South Wales, Australia.
Sreedhar AdapaDepartment of Internal Medicine, Adventist Health, Hanford, CA, USA.
Adventist Health Community Care-Hanford · USAshland (United States) · USUniversity of Nebraska Medical Center · USUniversity of New England · AUUniversity of Richmond · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute interstitial nephritis (AIN) classically presents as acute kidney injury most often induced by offending drugs. Less frequently it is secondary to infections, autoimmune disorders, or idiopathic conditions. Development of drug-related AIN is not dose dependent and a recurrence can occur with re-exposure to the drug. We present a 50-year-old male with treatment resistant schizoaffective disorder who developed clozapine-induced AIN, confirmed with kidney biopsy within 2 months of taking this medication. His kidney function improved with removal of the drug and treatment with steroids. However, his kidney function was again significantly impaired when rechallenged with even a lower dose of clozapine a year later. Kidney function returned to baseline after stopping clozapine. Monitoring of kidney function during clozapine therapy is essential to therapy. Prompt diagnosis is imperative as discontinuation of offending agent can prevent acute kidney injury.

Indexed as

Acute interstitial nephritisAcute kidney injuryClozapineDrug reactionsKidney biopsyRefractory schizophreniaSchizophrenia

Identifiers

PMID35949945
PMCPMC9332824
OpenAlexW4286253957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.