Evidence map›Paper›PMID 35949865›Full record

ArticleArchives of rheumatology2022

Biological treatment in resistant adult-onset Still's disease: A single-center, retrospective cohort study.

Seda Çolak, Emre Tekgöz, Maghrur Mammadov, Muhammet Çınar, Sedat Yılmaz

Abstract read
In one paragraph

Article in Archives of rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seda ÇolakDepartment of Internal Medicine, Division of Rheumatology, Gülhane Training and Research Hospital, Ankara, Turkey.
Emre TekgözDepartment of Internal Medicine, Division of Rheumatology, Gülhane Training and Research Hospital, Ankara, Turkey.ORCID 0000-0002-0866-1503
Maghrur MammadovDepartment of Internal Medicine, Division of Rheumatology, Gülhane Training and Research Hospital, Ankara, Turkey.ORCID 0000-0003-1657-8635
Muhammet ÇınarDepartment of Internal Medicine, Division of Rheumatology, Gülhane Training and Research Hospital, Ankara, Turkey.ORCID 0000-0002-6150-3539
Sedat YılmazDepartment of Internal Medicine, Division of Rheumatology, Gülhane Training and Research Hospital, Ankara, Turkey.ORCID 0000-0002-4691-3417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The aim of this study was to assess the demographic and clinical characteristics of patients with adult-onset Still's disease (AOSD) under biological treatment. Patients and methods: This retrospective cohort study included a total of 19 AOSD patients (13 males, 6 females; median age: 37 years; range, 28 to 52 years) who received biological drugs due to refractory disease between January 2008 and January 2020. The data of the patients were obtained from the patient files. The response to the treatment was evaluated based on clinical and laboratory assessments at third and sixth follow-up visits. Results: Interleukin (IL)-1 inhibitor was prescribed for 13 (68.4%) patients and IL-6 inhibitor prescribed for six (31.6%) patients. Seventeen (89.5%) patients experienced clinical remission. Conclusion: Biological drugs seem to be effective for AOSD patients who are resistant to conventional therapies. Due to the administration methods and the high costs of these drugs, however, tapering the treatment should be considered, after remission is achieved.

Indexed as

Adult-onset Still’s diseaseanakinratocilizumabtreatment

Identifiers

PMID35949865
PMCPMC9326374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.