ArticleHepatology forum2020
Serum zinc level and dietary zinc intake status in non-alcoholic fatty liver disease: A meta-analysis and systematic review.
Article in Hepatology forum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Zinc accumulation in macrophages exacerbates metabolic dysfunction-associated steatotic liver disease progression.Signal transduction and targeted therapy · 2026Article
- Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency.bioRxiv : the preprint server for biology · 2026Article
- Serum Levels of Trace Elements and Minerals in Non-alcoholic Fatty Liver Disease Patients with and without Type 2 Diabetes are Associated with Metabolic Risk Markers.Biological trace element research · 2026Article
- Food Nutrients and Bioactive Compounds for Managing Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review.Nutrients · 2025Review
- Dietary Intake of Major Minerals and Trace Elements in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Implications for Dietary Intervention.Advances in therapy · 2025Article
- Negative association of composite dietary antioxidant index with risk of hepatic fibrosis in individuals underwent cholecystectomy: a cross-sectional study.Scientific reports · 2025Article
- Article
- Supplementation of Micro- and Macronutrients-A Role of Nutritional Status in Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2024Review
- Synergistic impact of Composite Dietary Antioxidant Index and physical activity on fatty liver disease.Frontiers in nutrition · 2024Article
- Article
- Article
- Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives.Nutrients · 2023Review
- The impact of zinc supplementation on galectin-3 and metabolic markers in diabetic patients on hemodialysis: A randomized, double-blind, placebo-controlled trial.Journal of diabetes and metabolic disorders · 2022Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
- The role of zinc in the prevention and treatment of nonalcoholic fatty liver disease.Metabolism open · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is a common health problem related to diet and a sedentary lifestyle. Zinc has essential roles in diabetes, insulin resistance and inflammation. This meta-analysis aims to evaluate the relationship between NAFLD and dietary zinc intake/serum zinc levels. Materials and Methods: A systematic search was performed in PubMed, Web of Science, and Scopus databases for relevant English articles with mean/standard deviation values of serum zinc levels (µg/dL) and dietary zinc intake (mg/day) up to February 2020. We screened "fatty liver disease" and "zinc" keywords; totally 864 articles, eight of them were found to have suitable serum zinc level or daily zinc intake data for meta-analysis. Results: Serum zinc level in NAFLD patients were lower than healthy controls (data from 984 individuals, FEM, p<0.00001). The meta-analysis results of the nutritional zinc intake of totally 19438 individuals were similar in NAFLD and control groups (FEM, p=0.36). Conclusion: Serum zinc levels were lower in NAFLD patients, even though they have similar zinc intake in the diet, which suggests that there may be an absorption problem or increased need, with a distributional disorder which results in lower serum zinc levels. Further studies need to evaluate the role of zinc in NAFLD.
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