Evidence map›Paper›PMID 35949429›Full record

ArticleWorld journal of clinical oncology2022

Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients: Six case reports.

Afshin A Khan, Bassam N Estfan, Anirudh Yalamanchali, Djibril Niang, Erica C Savage, Clifton G Fulmer, Hailey L Gosnell, Jamak Modaresi Esfeh

Open access · diamondAbstract readCase Reports
In one paragraph

Article in World journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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  10. Imaging of cystic fibrosis manifestations in the abdomen.Abdominal radiology (New York) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Afshin A KhanDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States. khana13@ccf.org.
Bassam N EstfanDepartment of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Anirudh YalamanchaliDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Djibril NiangDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Erica C SavageDepartment of Pathology, Cleveland Clinic, Cleveland, OH 44195, United States.
Clifton G FulmerDepartment of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Hailey L GosnellDepartment of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Jamak Modaresi EsfehDepartment of Gastroenterology, Hepatology and Nutrition , Cleveland Clinic, Cleveland, OH 44195, United States.
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpstein-Barr virus associated smooth muscle tumor (EBV-SMT) is a rare oncological entity. However, there is an increasing incidence of EBV-SMTs, as the frequency of organ transplantation and immunosuppression grows. EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder (PTLD). There is no clear consensus on the treatment of EBV-SMTs. However, surgical resection, chemotherapy, radiation therapy, and immunosuppression reduction have been explored with varying degrees of success. CASE SUMMARY: Our case series includes six cases of EBV-SMTs across different age groups, with different treatment modalities, adding to the limited existing literature on this rare tumor. The median latency time between immunosuppression and disease diagnosis is four years. EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.

conclusionIt is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals.

Indexed as

Case reportEpstein-Barr virusEpstein-Barr virus-associated smooth muscle tumorsHuman immunodeficiency virusImmunocompromisedLiving related kidney transplantOrthotopic heart transplantOrthotopic liver transplantPost-transplant lymphoproliferative disordersSmooth muscle tumorsSolid Organ Transplant

Identifiers

PMID35949429
PMCPMC9244966
OpenAlexW4283012656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.