Evidence map›Paper›PMID 35949216›Full record

ArticleWorld journal of gastrointestinal oncology2022

Glutamine deprivation impairs function of infiltrating CD8

Wei Wang, Meng-Nan Guo, Ning Li, De-Quan Pang, Jing-Hua Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
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  8. Article
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  10. Review
  11. Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Harnessing CD8Clinical and translational medicine · 2024
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei WangDepartment of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, North China University of Science and Technology, Tangshan 063000, Hebei Province, China.
Meng-Nan GuoDepartment of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, North China University of Science and Technology, Tangshan 063000, Hebei Province, China.
Ning LiDepartment of Laboratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, Hebei Province, China.
De-Quan PangDepartment of Oncology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, Hebei Province, China.
Jing-Hua WuDepartment of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, North China University of Science and Technology, Tangshan 063000, Hebei Province, China. tswujinghua@163.com.
North China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe functions of infiltrating CD8

aimTo investigate whether and how glutamine metabolism affects the function of infiltrating CD8

methodsImmunohistochemical staining and immunofluorescence were performed on surgically resected liver tissues from patients. Differentially expressed genes in infiltrating CD8

resultsThere were a large number of infiltrating PD-1

conclusionGlutamine deprivation impairs the function of infiltrating CD8

Indexed as

CD8+ T cellsGlutamineHepatocellular carcinomaMitochondrial damageT cell function

Identifiers

PMID35949216
PMCPMC9244988
OpenAlexW4281608255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.