Evidence map›Paper›PMID 35949134›Full record

SynthesisAnatolian journal of cardiology2022

Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Low-risk Patients: A Meta-Analysis Based on a 2-Year Follow-Up.

Chang-Gan Chen, Bei-Bei Xi, Qiu-Feng Deng, Xin-Yuan Zhang, Wei-Cheng Lin, Liang-Wan Chen, Zhi-Huang Qiu

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Anatolian journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chang-Gan ChenDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Bei-Bei XiDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Qiu-Feng DengDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Xin-Yuan ZhangDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Wei-Cheng LinDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Liang-Wan ChenDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Zhi-Huang QiuDepartment of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery Fujian Medical University, Fujian Province University, Fujian, China.
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that transcatheter aortic valve implantation is the best alternative therapy to surgical aortic valve replacement in high-risk surgical patients with aortic stenosis. However, it is not clear whether transcatheter aortic valve implantation can be utilized in low-risk surgical patients with aortic stenosis. This studyaimed to evaluate the safety and efficacy of transcatheter aortic valve implantation in low-risk patients.

methodsFrom the outset of our initiative until April 2022, PubMed, EMBASE, and the Cochrane database were thoroughly searched, yielding the selection of 3 randomized controlled trials including 2644 patients with aortic stenosis, to assess outcome measures at distinct follow-up time.

resultsThe mean Society of Thoracic Surgeons Predicted Risk of Mortality score of patients was 2.2. At the 30-day and 1-year follow-up, transcatheter aortic valve implan- tation was associated with a lower incidence of all-cause mortality, cardiovascular mor- tality, acute kidney injury (stage 2 or 3), life-threatening or significant bleeding, and new atrial fibrillation but an increased risk of permanent pacemaker implantation. At the 2-year follow-up, transcatheter aortic valve implantation only had an advantage in new atrial fibrillation (relative risk, 0.27; 95% CI, 0.14-0.51; P < .0001), with no significant differ- ence in all-cause mortality or cardiovascular mortality.

conclusionsFor low-risk surgical patients with aortic stenosis, compared to surgical aortic valve replacement, transcatheter aortic valve implantation was associated with lower all-cause mortality at 30-day follow-up and lower cardiovascular mortality at 1-year follow-up. Except for the advantages in new atrial fibrillation, transcatheter aor- tic valve implantation had no significant impact on mortality at 2-year follow-up.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAortic ValveAtrial FibrillationFollow-Up StudiesHumansRiskTreatment Outcome

Identifiers

PMID35949134
PMCPMC9682548
OpenAlexW4283803009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.