Evidence map›Paper›PMID 35949130›Full record

ArticleAnatolian journal of cardiology2022

Eosinophil-to-Monocyte Ratio as a Candidate for a Novel Prognostic Marker in Acute Pulmonary Embolism: Is it a Consumptive Mechanism?

Şeyhmus Külahçıoğlu, Hacer Ceren Tokgöz, Özgür Yaşar Akbal, Berhan Keskin, Barkın Kültürsay, Seda Tanyeri, Doğancan Çeneli, Kadir Bıyıklı, Ali Karagöz, Süleyman Çağan Efe and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Anatolian journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Şeyhmus KülahçıoğluDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Hacer Ceren TokgözUniversity Health Science, Kartal Koşuyolu Heart and Research Hospital, Department of Cardiology, İstanbul, Turkey.
Özgür Yaşar AkbalUniversity Health Science, Kartal Koşuyolu Heart and Research Hospital, Department of Cardiology, İstanbul, Turkey.
Berhan KeskinDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Barkın KültürsayDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Seda TanyeriDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Doğancan ÇeneliDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Kadir BıyıklıDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Ali KaragözDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Süleyman Çağan EfeDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
İbrahim Halil TanboğaDepartment of Biostatistics, Nişantaşı University, İstanbul, Turkey.
Nihal ÖzdemirDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Cihangir KaymazDepartment of Cardiology, University of Health Sciences, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, Turkey.
Sağlık Bilimleri Üniversitesi · TRKartal Koşuyolu High Specialization Training and Research Hospital · TRIstanbul University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of eosinophils in thrombotic processes is well known, and the prognostic value of eosinophil to monocyte ratio had been determined in patients with ST elevated myocardial infarction and acute ischemic stroke in recent studies. We aimed to evaluate the impact of the eosinophil-to-monocyte ratio on short- and long-term allcause mortality in patients with pulmonary embolism, which is another clinical condition closely related to the thrombotic pathway.

methodsIn this study, a total of 212 retrospectively evaluated patients with intermediate-high risk and high-risk pulmonary embolism who underwent catheter-directed therapies with ultrasound-assisted thrombolysis or rheolytic thrombectomy (Angiojet©) and intravenous thrombolytic treatment were included.

resultsThe median Pulmonary Embolism Severity Index score was 105 (86-128; interquartile range: 25-75, min-max: 35-250). The intermediate-high status and high-risk status were noted in 83.5% and 16.5% of the patients, respectively. All of the reperfusion strategies resulted in significant improvements in the measures of pulmonary arterial pressure and right ventricular strain. Death was recorded in 42 (18.6%) patients during the follow-up period (median 1029 days, interquartile range: 651-1358). Multiple Cox regression analysis revealed that a higher pulmonary embolism severity index score (from 85 to 128; hazard ratio=3.00; 95% CI: 2.11-4.29; P < .001) and a lower eosinophil-to-monocyte ratio (from 0.02 to 0.24; hazard ratio=0.56; 95% CI: 0.34-0.98; P = .032) were 2 independent predictors for long-term all-cause mortality. The eosinophil-to-monocyte ratio at the admission of less than 0.03 was documented to be associated with higher mortality (P < .001).

conclusionOur results revealed that a lower eosinophil-to-monocyte ratio and a higher pulmonary embolism severity index score independently predict the long-term mortality in patients with intermediate-high- and high-risk pulmonary embolism.

Indexed as

Ischemic StrokePulmonary EmbolismAcute DiseaseEosinophilsHumansMonocytesPrognosisRetrospective StudiesThrombolytic TherapyTreatment Outcome

Identifiers

PMID35949130
PMCPMC9524210
OpenAlexW4286470711

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.