Evidence map›Paper›PMID 35949113›Full record

ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2022

Investigation of a common canine factor VII deficiency variant in dogs with unexplained bleeding on autopsy.

Jessica A Clark, Stephen B Hooser, Dayna L Dreger, Grant N Burcham, Kari J Ekenstedt

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jessica A ClarkDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.ORCID https://orcid.org/0000-0001-5602-6670
Stephen B HooserAnimal Disease Diagnostic Laboratory, Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Dayna L DregerDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA. Current address: National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Grant N BurchamAnimal Disease Diagnostic Laboratory, Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.ORCID https://orcid.org/0000-0002-2443-6461
Kari J EkenstedtDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Purdue University West Lafayette · US

Funding

The Baylor-Hopkins Clinical Genomics Center for All of UsOT2OD002751 · OD · BAYLOR COLLEGE OF MEDICINE · PI BOERWINKLE, ERIC A., DOHENY, KIMBERLY F · 2018 to 2023
$152.8M
Novel Genetic Models for Vertebral AbnormalitiesK01OD027051 · OD · PURDUE UNIVERSITY · PI EKENSTEDT, KARI J · 2019 to 2023
$627k
NIH HHS K01 OD027051NIH HHS OT2 OD002751
6 · The paper itself

Abstract

The factor VII (FVII) protein is an integral component of the extrinsic coagulation pathway. Deleterious variants in the gene encoding this protein can result in factor VII deficiency (FVIID), a bleeding disorder characterized by abnormal (slowed) clotting with a wide range of severity, from asymptomatic to life-threatening. In canids, a single FVIID-associated variant, first described in Beagles, has been observed in 24 breeds and mixed-breed dogs. Because this variant is present in breeds of diverse backgrounds, we hypothesized that it could be a contributing factor to unexplained bleeding observed in some canine autopsy cases. DNA was extracted from paraffin-embedded tissue samples from 67 anticoagulant-negative autopsy cases with unexplained etiology for gross lesions of hemorrhage. Each dog was genotyped for the c.407G>A (

Indexed as

Dog DiseasesFactor VII DeficiencyAnimalsAnticoagulantsAutopsyDogsFactor VIIHemorrhageMutationRetrospective StudiesAnticoagulantsFactor VIIbleeding disorderscoagulopathydogsfactor VIImissense mutation

Identifiers

PMID35949113
PMCPMC9446296
OpenAlexW4291002158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.