Evidence map›Paper›PMID 35948973›Full record

SynthesisAnnals of clinical microbiology and antimicrobials2022

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis.

Vicente A Benites-Zapata, Juan R Ulloque-Badaracco, Esteban A Alarcon-Braga, Enrique A Hernandez-Bustamante, Melany D Mosquera-Rojas, D Katterine Bonilla-Aldana, Alfonso J Rodriguez-Morales

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of clinical microbiology and antimicrobials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06156566 (European Randomised Clinical Trial on mPOX Infection), which is not on this map. Cited by 71 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 6 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06156566 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

European Randomised Clinical Trial on mPOX Infection

TypeinterventionalSponsorMiquel EkkelenkampRan2024 to 2026Enrolled150ConditionsMonkeypoxArmsTecovirimat Oral Capsule, Placebo
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 6 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Vicente A Benites-ZapataEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
Juan R Ulloque-BadaraccoEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
Esteban A Alarcon-BragaEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
Enrique A Hernandez-BustamanteSociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Trujillo, Trujillo, Perú.
Melany D Mosquera-RojasEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
D Katterine Bonilla-AldanaGrupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia.
Alfonso J Rodriguez-MoralesGrupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia. arodriguezmo@cientifica.edu.pe.
Peruvian University of Applied Sciences · PEFundación Universitaria Autónoma De Las Américas · COUniversidad San Ignacio de Loyola · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA multicountry monkeypox disease (MPX) outbreak began in May 2022 in Europe, leading to the assessment as a potential Public Health Emergency of International Concern (PHEIC) on June 23, 2022. Some observational studies have partially characterised clinical features, hospitalisations, and deaths. However, no systematic reviews of this MPX outbreak have been published.

methodsWe performed a systematic review with meta-analysis, using five databases to assess clinical features, hospitalisations, complications and deaths of MPX confirmed or probable cases. Observational studies, case reports and case series, were included. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95% CI). In addition, we carried out a subgroup analysis according to the continents and a sensitivity analysis excluding studies classified as having a high risk of bias.

resultsA total of 19 articles were included, using only 12 articles in the quantitative synthesis (meta-analysis). For 1958 patients, rash (93%, 95% CI 80-100%), fever (72%, 95% CI 30-99%), pruritus (65%, 95% CI 47-81%), and lymphadenopathy (62%, 47-76%), were the most prevalent manifestations. Among the patients, 35% (95% CI 14-59%) were hospitalised. Some 4% (95% CI 1-9%) of hospitalised patients had fatal outcomes (case fatality rate, CFR).

conclusionMPX is spreading rapidly, with a third of hospitalised patients, but less than 5% with fatal outcomes. As this zoonotic virus spreads globally, countries must urgently prepare human resources, infrastructure and facilities to treat patients according to the emerging guidelines and the most reliable clinical information.

Indexed as

Mpox, MonkeypoxDisease OutbreaksEuropeFeverHospitalizationHumansClinical featuresEpidemicLaboratoryMonkeypoxOrthopoxvirusOutcomesPoxviridaeZoonotic

Identifiers

PMID35948973
PMCPMC9364300
OpenAlexW4291019426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.