Evidence map›Paper›PMID 35948940›Full record

ArticleThyroid research2022

Management of malignant struma ovarii: is aggressive therapy justified? Case report and literature review.

Letiția Leuștean, Maria-Christina Ungureanu, Cristina Preda, Stefana Catalina Bilha, Florin Obrocea, Radu Dănilă, Laura Stătescu, Delia Gabriela Apostol Ciobanu

Open access · goldAbstract read
In one paragraph

Article in Thyroid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. BenignOxford medical case reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Malignant struma ovarii in pregnancy: A case report.Gynecologic oncology reports · 2024
    Article
  11. Article
  12. Article
  13. Struma Ovarii: Single Center Experience.Sisli Etfal Hastanesi tip bulteni · 2024
    Article
  14. Successful Management and Long-term Survival of Malignant Struma Ovarii with Radioactive Iodine Therapy.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Letiția LeușteanDepartment of Endocrinology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania.
Maria-Christina UngureanuDepartment of Endocrinology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania.
Cristina PredaDepartment of Endocrinology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania.
Stefana Catalina BilhaDepartment of Endocrinology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania. stefanabilha@gmail.com.
Florin ObroceaGreen Onco-Medical Bucuresti, București, Romania.
Radu DănilăDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania.
Laura StătescuDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania.
Delia Gabriela Apostol CiobanuDepartment of Pathology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Iasi, Romania.
Grigore T. Popa University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStruma ovarii (SO) is a rare ovarian teratoma containing predominantly thyroid tissue. In rare situations SO may develop malignancy. Most cases of malignant struma ovarii (MSO) are diagnosed after surgical removal, based on histopathological examination. There are still controversies regarding the extent of surgery and postoperative management in MSO, due to its unpredictable behavior, possible risk of metastasis and relatively high rate of recurrence. CASE PRESENTATION: We present the case of a patient diagnosed with a right ovarian cyst discovered incidentally during routine ultrasound examination. Its rapid growth and pelvic MRI raised the suspicion of a neoplastic process. She underwent total hysterectomy and bilateral adnexectomy. The anatomopathological diagnosis was MSO with follicular variant of papillary thyroid carcinoma. Prophylactic total thyroidectomy was performed, followed by radioactive iodine ablation (RAI), and suppressive therapy with levothyroxine. At 1 year follow-up, the patient was disease free.

conclusionsEven if latest literature reports consider that completion of local surgery with total thyroidectomy and RAI might be too aggressive in cases of MSO without extraovarian extension, in our case it was decided to follow the protocol for primary thyroid carcinoma, in order to reduce the recurrence risk.

Indexed as

Malignant struma ovariiRadioactive iodine ablationSurgeryTeratomaThyroid carcinoma

Identifiers

PMID35948940
PMCPMC9367145
OpenAlexW4290985855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.