ArticleNature2022
Spatial multi-omic map of human myocardial infarction.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 456 papers.
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456citing papers in PubMed
48.1field-weighted citation impact, top 1% of its field
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Who cites it
456 citing papers in PubMed, 620 citations in OpenAlex.
- A core-shell microneedle patch coordinates early anti-inflammatory modulation and sustained pro-angiogenic stimulation for cardiac repair after myocardial infarction.Materials today. Bio · 2026Article
- Human adult and pediatric multimodal transcriptomic atlas of progression from pressure-loaded to failing right ventricle.Nature cardiovascular research · 2026Article
- Roles of inflammation and metabolic dysfunction in cardiovascular diseases: molecular mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- CKD disrupts cardiac energy metabolism and aggravates cardiac inflammation, oxidative stress, and dysfunction post-infarction.Cardiovascular research · 2026Article
- Integrated single-cell multiomics reveals neutrophil-driven immune-metabolic reprogramming of Kupffer cells via thrombospondin-1/CD36 after surgical stress.JCI insight · 2026Article
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Macrophage heterogeneity in organ fibrosis in the era of single-cell omics.Molecular biology reports · 2026Review
- Human pericardial macrophages suppress cardiac fibrosis through cystatin C signaling after myocardial infarction.JCI insight · 2026Article
- NEAT1 Coordinates a PDLIM5-CACNA1C Regulatory Program Associated with a Potentially Arrhythmogenic Cardiomyocyte State in the Border Zone During Early Myocardial Infarction.International journal of molecular sciences · 2026Article
- Fate-mapping infiltrating monocytes following experimental myocardial infarction reveals differentiation trajectories in the infarcted heart.The Journal of clinical investigation · 2026Article
- Reversing the pipeline: a 'human-first' multi-omics approach to cardiovascular discovery.Experimental & molecular medicine · 2026Review
- Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics.Nature cardiovascular research · 2026Article
- Data-driven identification of cell subtypes for single-cell transcriptomic data with Subtypist.Briefings in bioinformatics · 2026Article
- Multi-omics analysis of early reperfused ischemic heart reveals ERRβ/γ activation protects against acute myocardial infarction injury.Journal of advanced research · 2026Article
- A Single-Cell Proteomic Atlas of Cardiac Fibrosis Reveals Cell-Type-Specific Remodeling and Discordant Protein Regulation.Proteomics · 2026Article
- Inflammaging and cytokine-driven cardiovascular senescence in age-related myocardial infarction: mechanisms, biomarkers, and precision immunotherapy strategies.Biogerontology · 2026Review
- Targeting NR4A1 (Nur77) in Macrophage Polarization: Molecular Mechanisms and Translational Prospects for Cardiac Repair After Myocardial Infarction.International journal of molecular sciences · 2026Review
- Genetics-Informed Mapping Identifies a CRIM1-Associated Endocardial Inflammatory Remodeling State in Acute Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Beyond Earth: Recent Advancements in Microgravity Biomedical and Genetic Research in Saudi Arabia.International journal of molecular sciences · 2026Review
- Multi-omics-driven precision medicine.iMeta · 2026Review
396 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 12 institutions in 5 countries.
Christoph Kuppe *Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0003-4597-9833
Ricardo O Ramirez Flores *Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0087-371X
Zhijian Li *Institute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0002-1523-1333
Sikander HayatInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Rebecca T LevinsonInstitute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
Xian LiaoInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Monica T HannaniInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0002-4123-6832
Jovan TanevskiInstitute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7177-1003
Florian WünnemannInstitute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
James S NagaiInstitute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Maurice HalderInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0003-2386-9684
David SchumacherInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0002-2308-6543
Sylvia MenzelInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Gideon SchäferInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Konrad HoeftInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0002-0265-0061
Mingbo ChengInstitute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Susanne ZieglerInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Xiaoting ZhangInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Fabian PeiskerInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0003-0123-8179
Nadine KaeslerInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Turgay SaritasInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0002-6691-9218
Yaoxian XuInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Astrid KassnerErich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.
Jan GummertHeart and Diabetes Center, North Rhine-Westphalia, Bad Oeynhausen, Germany.
Michiel MorshuisHeart and Diabetes Center, North Rhine-Westphalia, Bad Oeynhausen, Germany.
Junedh AmruteDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6851-0168
Rogier J A VeltropInstitute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0002-1386-820X
Peter BoorDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0001-9921-4284
Karin KlingelCardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Linda W Van LaakeDepartment of Cardiology, Regenerative Medicine Center and Circulatory Health Lab, University Medical Center Utrecht, Utrecht, The Netherlands.
Aryan VinkDepartment of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-9371-8788
Remco M HoogenboezemDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Eric M J BindelsDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9502-669X
Leon SchurgersInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0001-7867-6957
Susanne SattlerNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-9932-4109
Denis SchapiroInstitute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9391-5722
Rebekka K SchneiderInstitute of Cell and Tumor Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Kory LavineDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-1948-9945
Hendrik MiltingErich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.
Ivan G CostaInstitute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID http://orcid.org/0000-0003-2890-8697
Julio Saez-RodriguezInstitute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany. pub.saez@uni-heidelberg.de.ORCID http://orcid.org/0000-0002-8552-8976
Rafael KramannInstitute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany. rkramann@gmx.net.ORCID http://orcid.org/0000-0003-4048-6351
RWTH Aachen University · DEHeidelberg University · DEHeart and Diabetes Center North Rhine-Westphalia · DEUniversitätsklinikum Aachen · DEErasmus MC Cancer Institute · NLMaastricht University · NLWashington University in St. Louis · USErasmus MC · NLImperial College London · GBOncode Institute · NLUniversity Medical Center Utrecht · NLUtrecht University · NL
Funding
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MEuropean Research Council ERC-COG 101043403European Research Council ERC-STG 101040726European Research Council ERC-STG 677448
Abstract
Myocardial infarction is a leading cause of death worldwide
Indexed as
Atrial RemodelingChromatin Assembly and DisassemblyGene Expression ProfilingMyocardial InfarctionSingle-Cell AnalysisVentricular RemodelingCase-Control StudiesChromatinEpigenomeHumansMyocardiumMyocytes, CardiacTime FactorsChromatin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.