Evidence map›Paper›PMID 35948605›Full record

ReviewPediatric research2023

Environmental influences on child health outcomes: cohorts of individuals born very preterm.

T Michael O'Shea, Monica McGrath, Judy L Aschner, Barry Lester, Hudson P Santos, Carmen Marsit, Annemarie Stroustrup, Crisma Emmanuel, Mark Hudak, Elisabeth McGowan and 3 more

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03061890 (Developmental Impact of Neonatal Intensive Care Unit), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03061890 completednot on this map

Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO)

Typeobservational_patient_registrySponsorAlbert Einstein College of MedicineRan2017 to 2023Enrolled600ConditionsPrematurity
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Defining the developmental exposome of the neonatal intensive care unit in preterm infants.Journal of exposure science & environmental epidemiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

T Michael O'SheaDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA. moshea52@email.unc.edu.
Monica McGrathDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Judy L AschnerDepartment of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ, USA.
Barry LesterDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.
Hudson P SantosBiobehavioral Laboratory, School of Nursing, The University of North Carolina, Chapel Hill, NC, USA.
Carmen MarsitGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Annemarie StroustrupDepartments of Pediatrics and Occupational Medicine, Epidemiology and Prevention, Zucker School of Medicine at Hofstra, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY, USA.
Crisma EmmanuelBiobehavioral Laboratory, School of Nursing, The University of North Carolina, Chapel Hill, NC, USA.
Mark HudakDepartment of Pediatrics, University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA.
Elisabeth McGowanWomen & Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Simran PatelDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Rebecca C FryInstitute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA.
program collaborators for Environmental influences on Child Health Outcomes
Johns Hopkins University · USUniversity of North Carolina at Chapel Hill · USBrown University · USClinical Research Institute · USAlbert Einstein College of Medicine · USEmory University · USNorthwell Health · USRTI International · USUniversity of Florida · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
The Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9M
ENVIRONMENTAL INFLUENCES ON NEURODEVELOPMENTAL OUTCOME IN INFANTS BORN VERY PRETERMUH3OD023347 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., MARSIT, CARMEN JOSEPH · 2018 to 2022
$18.4M
Developmental Impact of NICU Exposures (DINE)UH3OD023320 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ASCHNER, JUDY LYNN, STROUSTRUP, ANNEMARIE · 2018 to 2022
$14.5M
The Environmental Factors in FEtal to Childhood Trajectories CohortUH3OD035532 · OD · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Matthew J Blitz, Burton Rochelson · 2025 to 2026
$11.9M
Developmental Impact of NICU Exposures (DINE)UG3OD023320 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ASCHNER, JUDY LYNN, TEITELBAUM, SUSAN L · 2016 to 2017
$6.1M
Developmental Impact of NICU Exposures (DINE) phase IIUH3OD035513 · OD · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Judy Lynn Aschner, Annemarie Stroustrup · 2025 to 2026
$1.7M
Placental Origins of Positive Child Health OutcomesR03HD101413 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANTOS, HUDSON · 2020 to 2021
$149k
NICHD NIH HHS R03 HD101413NIEHS NIH HHS P30 ES010126NIH HHS UG3 OD023320NIH HHS UH3 OD023320NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD035513NIH HHS UH3 OD035532
6 · The paper itself

Abstract

The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) Program was designed to address solution-oriented research questions about the links between children's early life environment and their risks of pre-, peri-, and post-natal complications, asthma, obesity, neurodevelopmental disorders, and positive health. Children born very preterm are at increased risk for many of the outcomes on which ECHO focuses, but the contributions of environmental factors to this risk are not well characterized. Three ECHO cohorts consist almost exclusively of individuals born very preterm. Data provided to ECHO from cohorts can be used to address hypotheses about (1) differential risks of chronic health and developmental conditions between individuals born very preterm and those born at term; (2) health disparities across social determinants of health; and (3) mechanisms linking early-life exposures and later-life outcomes among individuals born very preterm. IMPACT: The National Institutes of Health's Environmental Influences on Child Health Outcomes Program is conducting solution-oriented research on the links between children's environment and health. Three ECHO cohorts comprise study participants born very preterm; these cohorts have enrolled, to date, 1751 individuals born in 14 states in the U.S. in between April 2002 and March 2020. Extensive data are available on early-life environmental exposures and child outcomes related to neurodevelopment, asthma, obesity, and positive health. Data from ECHO preterm cohorts can be used to address questions about the combined effects of preterm birth and environmental exposures on child health outcomes.

Indexed as

AsthmaPremature BirthChildChild HealthEnvironmental ExposureFemaleHumansInfant, Extremely PrematureInfant, Newborn

Identifiers

PMID35948605
PMCPMC9363858
OpenAlexW4291021190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.