Evidence map›Paper›PMID 35948592›Full record

ArticleScientific reports2022

Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18.

Yiming Chen, Yijie Chen, Wenwen Ning, Wen Zhang, Liyao Li, Xiaoying Wang, Yixuan Yin, Huimin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yiming Chen *Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Teaching Hospital of Zhejiang Chinese Medical University, No. 369, Kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China. cxy40344@163.com.
Yijie Chen *Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Teaching Hospital of Zhejiang Chinese Medical University, No. 369, Kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Wenwen NingThe Fourth School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Wen ZhangDepartment of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Teaching Hospital of Zhejiang Chinese Medical University, No. 369, Kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Liyao LiDepartment of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Teaching Hospital of Zhejiang Chinese Medical University, No. 369, Kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Xiaoying WangDepartment of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Teaching Hospital of Zhejiang Chinese Medical University, No. 369, Kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Yixuan YinDepartment of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Teaching Hospital of Zhejiang Chinese Medical University, No. 369, Kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Huimin ZhangThe Fourth School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Zhejiang Chinese Medical University · CNHangzhou Women’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the clinical predictive value of serum alpha-fetoprotein variants (AFP-L2, AFP-L3) in combination with maternal serum prenatal screening biomarkers in predicting fetal trisomy 21 and trisomy 18. We analyze the data of singleton pregnant women at 15-20

Indexed as

Down Syndromealpha-FetoproteinsBiomarkersChorionic Gonadotropin, beta Subunit, HumanFemaleHumansPregnancyPregnancy Trimester, SecondPrenatal DiagnosisTrisomyTrisomy 18 Syndromealpha-FetoproteinsBiomarkersChorionic Gonadotropin, beta Subunit, Human

Identifiers

PMID35948592
PMCPMC9365830
OpenAlexW4291020190

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.