Evidence map›Paper›PMID 35948487›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2022

Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling.

Zhi-Cheng Yao, Yueh-Hsun Yang, Jiayuan Kong, Yining Zhu, Ling Li, Calvin Chang, Chi Zhang, Jason Yin, Jeffrey Chao, Florin M Selaru and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Granular Hydrogels for Harnessing the Immune Response.Advanced healthcare materials · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Zhi-Cheng YaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-3086-6038
Yueh-Hsun YangTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Jiayuan KongDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Yining ZhuTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Ling LiDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Calvin ChangTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Chi ZhangDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Jason YinDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Jeffrey ChaoTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21213, USA.
Florin M SelaruDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Sashank K ReddyInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Hai-Quan MaoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-4262-9988
Johns Hopkins University · US

Funding

Biostimulatory nanofiber-hydrogel composite for soft tissue remodelingR01DE031488 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI AARON W JAMES, Hai-Quan Mao · 2022 to 2026
$2.8M
NIDCR NIH HHS R01 DE031488
6 · The paper itself

Abstract

Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue. A biostimulatory nanofiber-hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface-functionalized poly (ε-caprolactone) nanofiber fragments. The NHC mimics the microarchitecture of native soft tissue matrix, showing enhanced cell infiltration, immunomodulation, and proangiogenic properties. Here, injectability of the pre-formed NHC is improved by mechanical fragmentation, making it into micro-fragmented NHC (mfNHC) in a granular gel form as a stem cell carrier to deliver mesenchymal stem cells (MSCs) for soft tissue remodeling. The mfNHC shows a similar storage modulus but a significantly reduced injection force, as compared with the corresponding bulk NHC. When injected subcutaneously in a rat model, mfNHC-MSC constructs initiate an elevated level of host macrophage infiltration, more pro-regenerative polarization, and subsequently, improved angiogenesis and adipogenesis response when compared to mfNHC alone. A similar trend of host cell infiltration and pro-angiogenic response is detected in a swine model with a larger volume injection. These results suggest a strong potential for use of the mfNHC as an injectable carrier for cell delivery and soft tissue remodeling.

Indexed as

Mesenchymal Stem CellsNanofibersAnimalsHyaluronic AcidHydrogelsInjectionsRatsSwineTissue EngineeringHyaluronic AcidHydrogelsgranular hydrogelsmacrophagesnanofiber-hydrogel compositessoft tissue remodelingstem cell delivery

Identifiers

PMID35948487
PMCPMC9994419
OpenAlexW4292639899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.