Evidence map›Paper›PMID 35948258›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Economic Choice and Heart Rate Fractal Scaling Indicate That Cognitive Effort Is Reduced by Depression and Boosted by Sad Mood.

Andrew Westbrook, Xiao Yang, Lauren M Bylsma, Shimrit Daches, Charles J George, Andrew J Seidman, J Richard Jennings, Maria Kovacs

Open access · greenAbstract read
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025
    Article
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  15. Autonomic complexity dynamically indexes affect regulation in everyday life.Journal of psychopathology and clinical science · 2023
    Article
  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Andrew WestbrookDepartment of Cognitive, Linguistic & Psychological Sciences, Brown University, Providence, Rhode Island. Electronic address: andrew.westbrook@brown.edu.
Xiao YangDepartment of Psychology, Old Dominion University, Norfolk, Virginia.
Lauren M BylsmaDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Shimrit DachesDepartment of Psychology, Bar-Ilan University, Ramat-Gan, Israel.
Charles J GeorgeDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Andrew J SeidmanDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
J Richard JenningsDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Maria KovacsDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
University of Pittsburgh Medical Center · USBar-Ilan University · ILBrown University · USOld Dominion University · USUniversity of Pittsburgh · US

Funding

CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Does getting older signal improved mood repair for people with early-onset mood disorder histories? A longitudinal study of outcomes and mechanisms across middle ageR01MH113214 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOVACS, MARIA · 2017 to 2021
$2.9M
Subjective Cognitive Effort Indexes Sub-Criticality in the BrainK99MH125021 · NIMH · BROWN UNIVERSITY · PI WESTBROOK, JOHN ANDREW · 2021 to 2022
$211k
Dopamine and a Bias for Proximal Action in Cognitive EffortF32MH115600 · NIMH · BROWN UNIVERSITY · PI WESTBROOK, JOHN ANDREW · 2018 to 2020
$188k
NIMH NIH HHS F32 MH115600NIMH NIH HHS K99 MH125021NIMH NIH HHS R01 MH113214NIMH NIH HHS T32 MH018951
6 · The paper itself

Abstract

backgroundPeople with depression typically exhibit diminished cognitive control. Control is subjectively costly, prompting speculation that control deficits reflect reduced cognitive effort. Evidence that people with depression exert less cognitive effort is mixed, however, and motivation may depend on state affect.

methodsWe used a cognitive effort discounting task to measure propensity to expend cognitive effort and fractal structure in the temporal dynamics of interbeat intervals to assess on-task effort exertion for 49 healthy control subjects, 36 people with current depression, and 67 people with remitted depression.

resultsPeople with depression discounted more steeply, indicating that they were less willing to exert cognitive effort than people with remitted depression and never-depressed control subjects. Also, steeper discounting predicted worse functioning in daily life. Surprisingly, a sad mood induction selectively boosted motivation among participants with depression, erasing differences between them and control subjects. During task performance, depressed participants with the lowest cognitive motivation showed blunted autonomic reactivity as a function of load.

conclusionsDiscounting patterns supported the hypothesis that people with current depression would be less willing to exert cognitive effort, and steeper discounting predicted lower global functioning in daily life. Heart rate fractal scaling proved to be a highly sensitive index of cognitive load, and data implied that people with lower motivation for cognitive effort had a diminished physiological capacity to respond to rising cognitive demands. State affect appeared to influence motivation among people with current depression given that they were more willing to exert cognitive effort following a sad mood induction.

Indexed as

DepressionFractalsCognitionHeart RateHumansMotivationCognitive effortDepressionDetrended fluctuation analysisEffort discountingMood inductionVagal withdrawal

Identifiers

PMID35948258
PMCPMC10919246
OpenAlexW4296327586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.