Evidence map›Paper›PMID 35948176›Full record

ArticleActa biomaterialia2022

Single-injection COVID-19 subunit vaccine elicits potent immune responses.

Xiaoyong Zhou, Haozheng Wang, Ying Luo, Lei Cui, Ying Guan, Yongjun Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaoyong ZhouKey Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Haozheng WangKey Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Ying LuoSchool of Chemistry, Tiangong University, Tianjin 300387, China.
Lei CuiKey Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Ying GuanKey Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. Electronic address: yingguan@nankai.edu.cn.
Yongjun ZhangKey Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China; School of Chemistry, Tiangong University, Tianjin 300387, China. Electronic address: yongjunzhang@nankai.edu.cn.
Nankai University · CNTiangong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current vaccination schedules, including COVID-19 vaccines, require multiple doses to be administered. Single injection vaccines eliciting equivalent immune response are highly desirable. Unfortunately because unconventional release kinetics are difficult to achieve it still remains a huge challenge. Herein a single-injection COVID-19 vaccine was designed using a highly programmable release system based on dynamic layer-by-layer (LBL) films. The antigen, S1 subunit of SARS-CoV-2 spike protein, was loaded in CaCO

Indexed as

COVID-19Viral VaccinesAnimalsCOVID-19 VaccinesHumansImmunityMicePolyethylene GlycolsSARS-CoV-2Spike Glycoprotein, CoronavirusTanninsVaccines, SubunitCOVID-19 VaccinesPolyethylene GlycolsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TanninsVaccines, SubunitViral VaccinesCOVID-19 vaccinesPulsatile releaseSingle-injection vaccinesUnconventional release kinetics

Identifiers

PMID35948176
PMCPMC9357281
OpenAlexW4291021505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.