ArticleScience advances2022
Disruption of the circadian clock drives
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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0cells of the map it votes in
73citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 94 citations in OpenAlex.
- Modulating the gut microbiota to enhance immune checkpoint inhibitor efficacy in colorectal cancer: mechanisms, therapeutic strategies, and clinical perspectives.Gut microbes · 2026Review
- Time matters: circadian genetics and the molecular logic of human health and disease.Nature reviews. Genetics · 2026Review
- Synthetically engineered probiotic suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling.Cell reports. Medicine · 2026Article
- Role of capsaicin, circadian clock genes, and TRPV1 in colorectal carcinogenesis: Lessons and future directions.Journal of advanced research · 2026Review
- Circadian Rhythms in Colorectal Cancer: Recent Advances in Development and Treatment.Journal of clinical medicine research · 2026Review
- Atractylodes macrocephala polysaccharide orchestrates anti-tumor immunity via a dual-network mechanism targeting the gut microbiota and spleen.NPJ biofilms and microbiomes · 2026Article
- Real-world evidence for the impact of circadian clock on the benefit from immune checkpoint inhibitors in solid tumors.BMC cancer · 2026Article
- Advances in research on circadian rhythms and colorectal cancer.BMC medical genomics · 2026Review
- Circadian reprogramming by timed sodium intake reveals transcriptional pathways of daily salt handling in the colon.Science advances · 2026Article
- Article
- Biochemical mechanism of the mammalian circadian clock.FEBS letters · 2026Review
- Rhythms of risk: the intersection of clocks, cancer, and chronotherapy.The Journal of clinical investigation · 2026Review
- Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review).International journal of oncology · 2026Review
- Temporal dynamics in cancer immunotherapy: the interplay between circadian rhythms, tumor microenvironment, and immune checkpoint blockade.Journal of the National Cancer Center · 2026Review
- NSMF modulates replication stress to facilitate colorectal cancer progression.Nucleic acids research · 2026Article
- Circadian Clock Genes in Colorectal Cancer: From Molecular Mechanisms to Chronotherapeutic Applications.Biomedicines · 2026Review
- Senescence-circadian interplay stratifies patient prognosis and reveals immune remodeling heterogeneity in colorectal cancer.Frontiers in immunology · 2026Article
- Integrate bulk RNA and single-cell sequencing to identify prognostic genes associated with dietary restriction and circadian rhythm in colorectal cancer and conduct experimental verification.Clinical and experimental medicine · 2025Article
- Single‑cell RNA sequencing reveals fibroblast heterogeneity and identifies CLOCK as a key regulator in fibrotic skin diseases.Scientific reports · 2025Article
- LILRB4 regulates circadian disruption-induced mammary tumorigenesis via non-canonical WNT signaling pathway.Oncogene · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 1 country.
Sung Kook ChunDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8207-0034
Bridget M FortinDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9080-6443
Rachel C FellowsDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-6454-7062
Amber N HabowskiDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-1107-3208
Amandine VerlandeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-6794-4119
Wei A SongDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-7797-9163
Alisa L MahieuDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-1744-2211
Austin E Y T LefebvreDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8148-5369
Jason N SterrenbergDepartment of Medicine, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8006-4116
Leandro M VelezDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8371-2633
Michelle A DigmanDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-4611-7100
Robert A EdwardsDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9145-382X
Nicholas R PannunzioDepartment of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Marcus M SeldinDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8026-4759
Marian L WatermanDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.
Selma MasriDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-8619-8331
University of California, Irvine · US
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MShared Resource Core: Single Cell AnalysisU54CA217378 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D, LOWENGRUB, JOHN · 2018 to 2022
$9.7MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MIntegrative approaches to dissection of endocrine communicationDP1DK130640 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2021 to 2025
$3.2MCircadian Clock and Myc-dependent Regulation of Cellular TransformationR01CA259370 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Selma Masri · 2022 to 2026
$3.0MCircadian Clock Disruption and Colorectal CancerR01CA244519 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Selma Masri · 2020 to 2026
$3.0MRapid detection of CRLF2 rearrangements in Hispanic Ph-like ALL patients to access diagnosis and relapseR37CA266042 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Nicholas Pannunzio · 2022 to 2026
$2.5MCoordinated regulation of alternative pre-mRNA processing in colon cancerR01CA177651 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDWARDS, ROBERT ANDREW, HERTEL, KLEMENS J · 2014 to 2018
$2.4MA strategy for discovery of endocrine interactionsR00HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2020 to 2022
$745kTumor Macroenvironment and the Circadian Metabolic ClockK22CA212045 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI MASRI, SELMA · 2018 to 2020
$607kDevelopment of a strategy for endocrine axis discoveryK99HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SELDIN, MARCUS MICHAEL · 2018 to 2019
$268kNCI NIH HHS K22 CA212045NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA177651NCI NIH HHS R01 CA244519NCI NIH HHS R01 CA259370NCI NIH HHS R37 CA266042NCI NIH HHS T32 CA009054NCI NIH HHS U54 CA217378NHLBI NIH HHS K99 HL138193NHLBI NIH HHS R00 HL138193NIDDK NIH HHS DP1 DK130640
Abstract
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of young onset CRC include environmental aspects, such as lifestyle and dietary factors, which are known to affect the circadian clock. We find that both genetic disruption and environmental disruption of the circadian clock accelerate
Indexed as
Circadian ClocksColorectal NeoplasmsCircadian RhythmHumansLoss of HeterozygosityOrganoidsWnt Signaling Pathway
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