ArticlePloS one2022
Transcriptomic and metabonomic insights into the biocontrol mechanism of Trichoderma asperellum M45a against watermelon Fusarium wilt.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 37 citations in OpenAlex.
- Transcriptomic insights into the biocontrol mechanism of Trichoderma spp. against Fusarium wilt in melon.Stress biology · 2026Article
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- Omics-informed insights into biochar-Trichoderma interactions in plant-soil systems: mechanisms of defense and context-dependent responses.World journal of microbiology & biotechnology · 2026Review
- Genome-wide identification of the GATA transcription factor family in ten Cucurbitaceae species and expression analysis of ClGATA genes in watermelon stress responses.BMC genomics · 2026Article
- Multi-omics integration to elucidate the antibacterial mechanism of Streptomyces sp. strain PBSH9.BMC microbiology · 2026Article
- Genome-wide identification of HXK gene families in cucumber and watermelon: CsHXK1 and ClHXK6 play key roles in responding to multiple stresses.BMC plant biology · 2026Article
- Microbial biocontrol agents and the rhizosphere microbiome: integrating ecological function and climate resilience in sustainable agriculture.Frontiers in microbiology · 2026Review
- The distinct characteristics of the endophytic microbiome and metabolome within the root system result in varying abilities of watermelon resistance against Fusarium wilt.BMC plant biology · 2025Article
- The DIR Gene Family in Watermelon: Evolution, Stress Expression Profiles, and Functional Exploration ofInternational journal of molecular sciences · 2025Article
- Watermelon wilt disease: causes, harms, and control measures.Frontiers in microbiology · 2025Review
- Root exudates and microbial community structure characteristics of mango under soil borne diseases.Frontiers in microbiology · 2025Article
- Genetic diversity and antagonistic properties of Trichoderma strains from the crop rhizospheres in southern Rajasthan, India.Scientific reports · 2024Article
- Biocontrol potential of endophyticFrontiers in microbiology · 2024Article
- Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plants at elevated COFrontiers in microbiology · 2024Article
- Assessment of TunisianMicroorganisms · 2023Article
- Review
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Watermelon (Citrullus lanatus) is one of the most popular fruit crops. However, Fusarium wilt (FW) is a serious soil-borne disease caused by Fusarium oxysporum f. sp. niveum (FON) that severely limits the development of the watermelon industry. Trichoderma spp. is an important plant anti-pathogen biocontrol agent. The results of our previous study indicated that Trichoderma asperellum M45a (T. asperellum M45a) could control FW by enhancing the relative abundance of plant growth-promoting rhizobacteria (PGPR) in the rhizosphere of watermelon. However, there are few studies on its mechanism in the pathogen resistance of watermelon. Therefore, transcriptome sequencing of T. asperellum M45a-treated watermelon roots combined with metabolome sequencing of the rhizosphere soil was performed with greenhouse pot experiments. The results demonstrated that T. asperellum M45a could stably colonize roots and significantly increase the resistance-related enzymatic activities (e.g., lignin, cinnamic acid, peroxidase and peroxidase) of watermelon. Moreover, the expression of defense-related genes such as MYB and PAL in watermelon roots significantly improved with the inoculation of T. asperellum M45a. In addition, KEGG pathway analysis showed that a large number of differentially expressed genes were significantly enriched in phenylpropane metabolic pathways, which may be related to lignin and cinnamic acid synthesis, thus further inducing the immune response to resist FON. Furthermore, metabolic analysis indicated that four differential metabolic pathways were enriched in M45a-treated soil, including six upregulated compounds and one down-regulated compound. Among them, galactinol and urea were significantly positively correlated with Trichoderma. Hence, this study provides insight into the biocontrol mechanism of T. asperellum M45a to resist soil-borne diseases, which can guide its industrial application.
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