ArticleProceedings of the National Academy of Sciences of the United States of America2022
An intermediate-effect size variant in
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.Nature communications · 2024Pooled it
- New perspectives on thick ascending limb function and cell types.Kidney international · 2026Review
- Lipocalin-2 Is Induced by Uromodulin Aggregates without Affecting Kidney Disease Progression in Autosomal Dominant Tubulointerstitial Kidney Disease- UMOD.Journal of the American Society of Nephrology : JASN · 2026Article
- Uromodulin T62P variant causes kidney tubular stress and injury modulated by age and polygenic risk.medRxiv : the preprint server for health sciences · 2026Article
- Uromodulin p.His36Tyr promotes macrophage pyroptosis via App-Cd74 signaling to drive renal inflammation in ADTKD.Nature communications · 2026Article
- Imaging-based organ-specific aging clock predicts human diseases and mortality.NPJ digital medicine · 2026Article
- Plasma proteomics identify novel biomarkers and dynamic patterns of biological aging.Journal of advanced research · 2026Article
- Fifty Shades of Risk: Population Studies and the Genetic Architecture of Kidney Diseases.Journal of the American Society of Nephrology : JASN · 2026Review
- Diagnostic Yield of Whole-Genome Sequencing in Patients With Kidney Failure of Undetermined Etiology at Age 50 Years or Younger.Kidney international reports · 2025Article
- Multiomics Mendelian randomization integrating pQTL, eQTL and mQTL data revealed BTN3A2 as a potential drug target for nephrolithiasis.Scientific reports · 2025Article
- Autosomal dominant tubulointerstitial kidney disease-UMOD: a short review.Orphanet journal of rare diseases · 2025Review
- Characterization of Monogenic Kidney Disease in Older Patients With CKD.Kidney international reports · 2025Article
- The impact of a secondary, rare, non-pathogenic PKD1 variant on disease progression in autosomal dominant polycystic kidney disease.Journal of nephrology · 2025Article
- Endoplasmic reticulum stress as a driver and therapeutic target for kidney disease.Nature reviews. Nephrology · 2025Review
- Application of biomarkers in the diagnosis of kidney disease.Frontiers in medicine · 2025Review
- Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.The Journal of clinical investigation · 2024Article
- Article
- Advances in uromodulin biology and potential clinical applications.Nature reviews. Nephrology · 2024Review
- Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions.American journal of physiology. Renal physiology · 2024Review
- Chronic Kidney Disease Progression-A Challenge.Biomedicines · 2024Review
Corrections and comments
- Commented on by
Authors and funding
25 authors at 7 institutions in 9 countries.
Eric OlingerInstitute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.ORCID 0000-0003-1178-7980
Céline SchaefferMolecular Genetics of Renal Disorders, Division of Genetics and Cell Biology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan, 20132 Italy.ORCID 0000-0001-5883-3951
Kendrah KiddSection on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27101.
Elhussein A E ElhassanDivision of Nephrology, Beaumont General Hospital, 1297 Dublin, Ireland.ORCID 0000-0002-8689-8602
Yurong ChengInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, D-79106 Freiburg, Germany.
Inès DufourInstitute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.
Guglielmo SchianoInstitute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.ORCID 0000-0002-3549-7796
Holly MabillardTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom.ORCID 0000-0001-6725-7570
Elena PasqualettoMolecular Genetics of Renal Disorders, Division of Genetics and Cell Biology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan, 20132 Italy.ORCID 0000-0003-2130-1577
Patrick HofmannInstitute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.
Daniel G FusterDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0001-7220-1803
Andreas D KistlerDepartment of Medicine, Cantonal Hospital Frauenfeld, 8501 Frauenfeld, Switzerland.ORCID 0000-0002-4114-9560
Ian J WilsonBiosciences Institute, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom.
Stanislav KmochSection on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27101.ORCID 0000-0002-6239-707X
Laure RaymondGenetics Department, Laboratoire Eurofins Biomnis, Lyon, 69007 France.
Thomas RobertCentre de Néphrologie et Transplantation Rénale, Centre Hospitalier Universitaire (CHU) la Conception, Assistance Publique - Hôpitaux de Marseille (AP-HM), Marseille, 13005 France.ORCID 0000-0002-7580-0913
Genomics England Research Consortium
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0003-3823-0920
Anthony J BleyerSection on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27101.
Anna KöttgenInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, D-79106 Freiburg, Germany.
Peter J ConlonDivision of Nephrology, Beaumont General Hospital, 1297 Dublin, Ireland.
Michael WiesenerDepartment of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.ORCID 0000-0003-4992-3132
John A SayerTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom.ORCID 0000-0003-1881-3782
Luca RampoldiMolecular Genetics of Renal Disorders, Division of Genetics and Cell Biology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan, 20132 Italy.ORCID 0000-0002-0544-7042
Olivier DevuystInstitute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland.ORCID 0000-0003-3744-4767
Beth Israel Deaconess Medical Center · USCliniques Universitaires Saint-Luc · BENational Health Service · GBUniversity of Freiburg · DEAix-Marseille Université · FRFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Bern · CH
Funding
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
Abstract
The kidney-specific gene
Indexed as
Renal Insufficiency, ChronicUromodulinHeterozygoteHumansMutationUMOD protein, humanUromodulinAutosomal Dominant Tubulointerstitial Kidney DiseaseER stressgenetic architecturerare diseaseuromodulin
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.