Evidence map›Paper›PMID 35947145›Full record

ArticleCalcified tissue international2022

Guanylyl Cyclase-B Dependent Bone Formation in Mice is Associated with Youth, Increased Osteoblasts, and Decreased Osteoclasts.

Brandon M Wagner, Jerid W Robinson, Timothy C R Prickett, Eric A Espiner, Sundeep Khosla, Dana Gaddy, Larry J Suva, Lincoln R Potter

Abstract read
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In one paragraph

Article in Calcified tissue international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Brandon M WagnerDepartments of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.
Jerid W RobinsonDepartments of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN, USA.
Timothy C R PrickettDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Eric A EspinerDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Sundeep KhoslaRobert and Arlene Kogod Center on Aging and Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Dana GaddyDepartments of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Larry J SuvaDepartments of Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.
Lincoln R PotterDepartments of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA. potter@umn.edu.
University of Minnesota · USTexas A&M University · USUniversity of Otago · NZMayo Clinic · US

Funding

TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3M
Understanding the skeleton in Down SyndromeR01HD102909 · NICHD · TEXAS A&M AGRILIFE RESEARCH · PI SUVA, LARRY J. · 2021 to 2025
$2.8M
NICHD NIH HHS R01 HD102909NIDDK NIH HHS T32 DK007203
6 · The paper itself

Abstract

C-type natriuretic peptide (CNP) activation of guanylyl cyclase-B (GC-B) catalyzes the synthesis of cGMP in chondrocytes and osteoblasts. Elevated cGMP stimulates long bone growth, and inactivating mutations in CNP or GC-B reduce cGMP, which causes dwarfism. GC-B

Indexed as

Natriuretic Peptide, C-TypeOsteoclastsAnimalsCollagenCyclic GMPMaleMiceOsteoblastsOsteocalcinOsteogenesisRANK LigandRNA, MessengerCollagenCyclic GMPNatriuretic Peptide, C-TypeOsteocalcinRANK LigandRNA, MessengerAchondroplasiacGMPGuanylyl cyclaseNatriuretic peptideOsteoblastOsteoclast

Identifiers

PMID35947145
OpenAlexW4297826854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.