Evidence map›Paper›PMID 35946941›Full record

ArticleMicrobiology spectrum2022

Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus.

Shuai Wang, Xiaoyin Cai, Wei Yu, Sheng Zeng, Jingran Zhang, Lingmin Guo, Yamin Gao, Zhili Lu, H M Adnan Hameed, Cuiting Fang and 13 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  12. Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adaptedProceedings of the National Academy of Sciences of the United States of America · 2024
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  13. Drug resistantbioRxiv : the preprint server for biology · 2024
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  14. Drug-resistant strains ofFrontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 3 countries.

Shuai WangNational Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Shenzhen, China.
Xiaoyin CaiState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Wei YuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Sheng ZengState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Jingran ZhangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Lingmin GuoState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Yamin GaoState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Zhili LuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
H M Adnan HameedState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Cuiting FangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Xirong TianState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Buhari YusufState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Chiranjibi ChhotarayState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
M D Shah AlamState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Buchang ZhangInstitutes of Physical Science and Information Technology, Anhui University, Hefei, China.ORCID 0000-0002-2283-8117
Honghua GeInstitutes of Physical Science and Information Technology, Anhui University, Hefei, China.
Dmitry A MaslovLaboratory of Bacterial Genetics, Vavilov Institute of General Geneticsgrid.433823.d, Russian Academy of Sciences, Moscow, Russia.
Gregory M CookDepartment of Microbiology and Immunology, School of Biomedical Sciences, University of Otagogrid.29980.3a, Dunedin, New Zealand.
Jiacong PengGuangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Yongping LinGuangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Nanshan ZhongGuangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.
Guoliang ZhangNational Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Shenzhen, China.
Tianyu ZhangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Healthgrid.428926.3, Chinese Academy of Sciences, Guangzhou, China.ORCID 0000-0001-5647-6014
Chinese Academy of Sciences · CNGuangzhou Institutes of Biomedicine and Health · CNAnhui University · CNShenzhen Third People’s Hospital · CNUniversity of Auckland · NZUniversity of Science and Technology of China · CNVavilov Institute of General Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium abscessus is an emerging human pathogen leading to significant morbidity and even mortality, intrinsically resistant to almost all the antibiotics available and so can be a nightmare. Mechanisms of its intrinsic resistance remain not fully understood. Here, we selected and confirmed an M. abscessus transposon mutant that is hypersensitive to multiple drugs including rifampin, rifabutin, vancomycin, clofazimine, linezolid, imipenem, levofloxacin, cefoxitin, and clarithromycin. The gene

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousTuberculosisAnimalsAnti-Bacterial AgentsAntitubercular AgentsEthambutolHumansImipenemLinezolidMiceMice, KnockoutMicrobial Sensitivity TestsPentosyltransferasesPermeabilityRifabutinAnti-Bacterial AgentsAntitubercular AgentsarabinosyltransferaseEthambutolImipenemLinezolidPentosyltransferasesRifabutinintrinsic resistanceMAB_0189cMycobacterium abscessuspermeability

Identifiers

PMID35946941
PMCPMC9430846
OpenAlexW4292505841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.