Evidence map›Paper›PMID 35946825›Full record

SynthesisJournal of clinical periodontology2023

Treatment of periodontitis and C-reactive protein: A systematic review and meta-analysis of randomized clinical trials.

Shailly Luthra, Marco Orlandi, Syed Basit Hussain, Yago Leira, João Botelho, Vanessa Machado, José João Mendes, Debora Marletta, Simon Harden, Francesco D'Aiuto

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical periodontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Shailly LuthraPeriodontology Unit, UCL Eastman Dental Institute, London, UK.ORCID 0000-0001-7189-5946
Marco OrlandiPeriodontology Unit, UCL Eastman Dental Institute, London, UK.ORCID 0000-0002-1173-3029
Syed Basit HussainPeriodontology Unit, UCL Eastman Dental Institute, London, UK.ORCID 0000-0003-3767-2647
Yago LeiraPeriodontology Unit, UCL Eastman Dental Institute, London, UK.ORCID 0000-0001-5027-7276
João BotelhoPeriodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), Almada, Portugal.ORCID 0000-0002-1019-8263
Vanessa MachadoPeriodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), Almada, Portugal.ORCID 0000-0003-2503-260X
José João MendesEvidence-Based Hub, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), Almada, Portugal.
Debora MarlettaLibrary Services UCL, Eastman Dental Institute, London, UK.
Simon HardenDepartment of Statistical Science, UCL Eastman Dental Institute, London, UK.
Francesco D'AiutoPeriodontology Unit, UCL Eastman Dental Institute, London, UK.ORCID 0000-0001-8654-935X
Eastman Dental Hospital · GBEscola Superior de Saúde Egas Moniz · PTUniversidade de Santiago de Compostela · ES

Funding

Department of Health NIHR-INF-0387
6 · The paper itself

Abstract

backgroundSystemic inflammation is implicated in the onset and progression of several chronic diseases. Periodontitis is a potential trigger of systemic inflammation. PURPOSE: To comprehensively appraise all the evidence on the effects of the treatment of periodontitis on systemic inflammation assessed by serum C-reactive protein (CRP) levels. DATA SOURCES: Six electronic databases were searched up to 10 February 2022 to identify and select articles in English language only. STUDY SELECTION: Twenty-six randomized controlled clinical trials reporting changes amongst 2579 participants about CRP levels at 6 months or more after treatment. DATA EXTRACTION: Two reviewers independently extracted data and rated the quality of studies. Meta-analyses were performed using random and fixed effect models. RISK OF BIAS: Risk of bias (RoB 2.0 tool) and quality of evidence (GRADEpro GDT tool) analyses were completed. DATA SYNTHESIS: Treatment of periodontitis reduced CRP levels by 0.69 mg/L (95% confidence interval: -0.97 to -0.40) after 6 months, but limited evidence was retrieved from studies with longer follow-ups. Similar findings were observed in participants with other co-morbidities in addition to periodontitis. Greatest reductions were observed in participants with concentrations of CRP >3 mg/L at baseline. LIMITATIONS: High level of heterogeneity.

conclusionsTreatment of periodontitis reduces serum CRP levels (up to 6 months follow-up) to a degree equivalent to that observed after traditional lifestyle or drug interventions. This evidence supports a causal association between periodontitis and systemic inflammation.

Indexed as

C-Reactive ProteinPeriodontitisHumansInflammationRandomized Controlled Trials as TopicC-Reactive ProteinbiomarkersCRPinflammationmeta-analysisperiodontitis

Identifiers

PMID35946825
PMCPMC10087558
OpenAlexW4293516533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.