ArticleArquivos de neuro-psiquiatria2022
Diagnostic accuracy of CompCog: reaction time as a screening measure for mild cognitive impairment.
Article in Arquivos de neuro-psiquiatria, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 10 citations in OpenAlex.
- Prefrontal hemodynamic alterations during resting state and stroop interference in cognitively healthy older adults with high plasma pTau-217 levels.Neuroimage. Reports · 2026Article
- Scenario-Based Serious Game for Screening Mild Cognitive Impairment in Older Adults: Cross-Sectional Preliminary Validation Study.JMIR serious games · 2026Article
- Resilience among European geriatricians: a cross-sectional survey combining self-reported and performance-based measures.European geriatric medicine · 2026Article
- Article
- Lower locus coeruleus integrity is associated with diminished practice effects in clinically unimpaired older individuals.Neurobiology of aging · 2025Article
- Limited Evidence to Review-Is There an Association Between Cognition and Upper Extremity Motor Reaction Time in Older Adults?NeuroSci · 2025Review
- Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review.Journal of medical Internet research · 2025Article
- Reliability of remote self-administered digital cognitive assessments: preliminary validation study.Frontiers in digital health · 2025Article
- Establishing Reference Values for a New Computerized Cognitive Function Test Program for Children.Annals of rehabilitation medicine · 2024Article
- A Perspective: Challenges in Dementia Research.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReaction time is affected under different neurological conditions but has not been much investigated considering all types of mild cognitive impairment (MCI).
objectiveThis study investigated the diagnostic accuracy of CompCog, a computerized cognitive screening battery focusing on reaction time measurements.
methodsA sample of 52 older adults underwent neuropsychological assessments, including CompCog, and medical appointments, to be classified as a control group or be diagnosed with MCI. The accuracy of CompCog for distinguishing between the two groups was calculated.
resultsThe results from diagnostic accuracy analyses showed that the AUCs of ROC curves were as high as 0.915 (CI 0.837-0.993). The subtest with the highest sensitivity and specificity (choice reaction time subtest) had 91.7% sensitivity and 89.3% specificity. The logistic regression final model correctly classified 92.3% of individuals, with 92.9% specificity and 91.7% sensitivity, and included only four variables from different subtests.
conclusionsIn summary, the study showed that reaction time assessed through CompCog is a good screening measure to differentiate between normal aging and MCI. Reaction time measurements in milliseconds were more accurate than correct answers. This test can form part of routine clinical tests to achieve the objectives of screening for MCI, indicating further procedures for investigation and diagnosis and planning interventions.
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