Evidence map›Paper›PMID 35946474›Full record

ArticleJournal of the American Heart Association2022

Risk of Dementia Associated With Atrial Cardiopathy: The ARIC Study.

Michelle C Johansen, Wendy Wang, Michael Zhang, David S Knopman, Chiadi Ndumele, Thomas H Mosley, Elizabeth Selvin, Amil M Shah, Scott D Solomon, Rebecca F Gottesman and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. Associations of plasma HDL subclasses with incident dementia risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  15. Systemic determinants of brain health in ageing.Nature reviews. Neurology · 2024
    Review
  16. Review
  17. Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Michelle C JohansenDepartment of Neurology The Johns Hopkins University School of Medicine Baltimore MD.ORCID 0000-0003-0393-3589
Wendy WangDivision of Epidemiology and Community Health, School of Public Health University of Minnesota Minneapolis MN.ORCID 0000-0001-6025-0173
Michael ZhangCardiovascular Division, Department of Medicine University of Minnesota Medical School Minneapolis MN.ORCID 0000-0003-2537-2831
David S KnopmanDepartment of Neurology Mayo Clinic Rochester MN.ORCID 0000-0002-6544-066X
Chiadi NdumeleDepartment of Cardiology The Johns Hopkins University School of Medicine Baltimore MN.ORCID 0000-0002-1603-282X
Thomas H MosleyThe University of Mississippi Medical Center Jackson MI.ORCID 0000-0003-3343-1352
Elizabeth SelvinDepartment of Epidemiology The Bloomberg School of Public Health Baltimore MD.ORCID 0000-0001-6923-7151
Amil M ShahDepartment of Cardiology Harvard Medical School Boston MA.ORCID 0000-0003-1056-4451
Scott D SolomonDepartment of Cardiology Harvard Medical School Boston MA.ORCID 0000-0003-3698-9597
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program Bethesda MD.ORCID 0000-0002-9504-1256
Lin Yee ChenCardiovascular Division, Department of Medicine University of Minnesota Medical School Minneapolis MN.ORCID 0000-0002-0700-814X
Johns Hopkins University · USHarvard University · USUniversity of Minnesota Medical Center · USMayo Clinic in Arizona · USNational Institute of Neurological Disorders and Stroke · USUniversity of Minnesota · USUniversity of Mississippi Medical Center · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling ElderlyR01HL126637 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2016 to 2020
$3.7M
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive DeclineR01HL141288 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2018 to 2021
$2.1M
Defining the role of Atrial Cardiopathy and Subclinical Cardiac Disease in Acute Ischemic Stroke: Critical Life Event SupplementK23NS112459 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JOHANSEN, MICHELLE C. · 2020 to 2024
$1.0M
Mentoring and Research to ClassifyAtrial CardiomyopathyK24HL155813 · NHLBI · UNIVERSITY OF MINNESOTA · PI Lin Yee Chen · 2021 to 2026
$770k
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K24 HL152008NHLBI NIH HHS K24 HL155813NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL126637NHLBI NIH HHS R01 HL135008NHLBI NIH HHS R01 HL141288NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NINDS NIH HHS K23 NS112459
6 · The paper itself

Abstract

Background The contribution of atrial cardiopathy to dementia risk is uncharacterized. We aimed to evaluate the association of atrial cardiopathy with incident dementia and potential mediation by atrial fibrillation (AF) and stroke. Methods and Results We conducted a prospective cohort analysis of participants in the ARIC (Atherosclerosis Risk in Communities) study attending visit 5 (2011-2013). We used Cox regression to determine the association between atrial cardiopathy and risk of dementia. Structural equation modeling methods were used to determine potential mediation by AF and/or stroke. Atrial cardiopathy was defined if ≥1 of the following at visit 5: P-wave terminal force >5000 mV·ms in ECG lead V1, NT-proBNP (N-terminal pro-brain natriuretic peptide) >250 pg/mL or left atrial volume index ≥34 mL/m

Indexed as

Atrial FibrillationDementiaHeart DiseasesStrokeAgedBiomarkersFemaleHumansIncidenceMaleNatriuretic Peptide, BrainPeptide FragmentsProspective StudiesRisk FactorsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentsatrial cardiopathydementialeft atriumpopulation study

Identifiers

PMID35946474
PMCPMC9496312
OpenAlexW4293276101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.