Evidence map›Paper›PMID 35946439›Full record

ArticleOrthopaedic surgery2022

Transverse Tibial Bone Transport Enhances Distraction Osteogenesis and Vascularization in the Treatment of Diabetic Foot.

Shuanji Ou, Changpeng Xu, Yang Yang, Ya Chen, Wenjun Li, Hanyu Lu, Guitao Li, Hongtao Sun, Yong Qi

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Orthopaedic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07175129 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Transverse Tibial Bone Transport in "No Option" Patients With Chronic Limb-Threatening Ischemia: A Pilot Study

TypeinterventionalSponsorUniversity Hospitals Cleveland Medical CenterRan2026 to 2027Enrolled0ConditionsChronic Limb Threatening IschemiaArmsTransverse Tibial Bone Transport, TrueLok Elevate
NCT07444593 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

SMILE - TTT: Surgical MIcrovascularization of Lower Extremities for Diabetic Foot Ulcers - Transverse Tibial Transport Study

TypeinterventionalSponsorBiodynamik, IncRan2026 to 2027Enrolled100ConditionsDiabetic Foot Ulcer, Chronic Ulcers of the Lower LimbArmsBiodynamik XT3
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Tibial Osteodistraction Angiogenesis for Diabetic Foot Ischemia: A Systematic Review and Meta-Analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Pooled it
  3. [Effectiveness of tibial transverse transport combined with modified neurolysis in treatment of diabetic foot ulcers].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Trial
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  12. [Application of minimally invasive osteotomy with preservation of blood supply to transversely transported bone segment in tibial transverse bone transport].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Article
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  19. [Preliminary application of ulnar cortex transverse transport technique in treatment of upper extremity thromboangiitis obliterans].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shuanji OuDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Changpeng XuDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Yang YangDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Ya ChenDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Wenjun LiDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Hanyu LuDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Guitao LiDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Hongtao SunDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.
Yong QiDepartment of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, China.ORCID https://orcid.org/0000-0002-7184-1216
Guangdong Provincial People's Hospital · CNHealth First · US

Funding

Fund of Guangdong Second People's Hospital 3D-A2020002Fund of Guangdong Second People's Hospital YQ2019-009Guangzhou Science and Technology Plan Project 201804010226National Natural Science Foundation of China 81972083Natural Science Foundation of Guangdong Province 2017A030313736
6 · The paper itself

Abstract

objectiveTo investigate the effect of transverse tibial bone transport on the treatment of Wagner Stage 4 diabetic foot.

methodsFrom January 2017 to October 2019, a total of 19 patients with Wagner Stage 4 diabetic foot ulcers were recruited. All patients were treated with transverse tibial bone transport. A detailed follow-up was carried out at 1 week, 1 month, 3 months, 6 months, and 1 year after surgery. The wound healing rate and the limb salvage rate at 1 year after the surgery were evaluated. Preoperative and 3-month postoperative digital subtraction angiography (DSA) were obtained. The level of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) before surgery and on 1st, 4th, 11th, 18th, 28

resultsThe wound healing rate and the limb salvage rate were both 94.74% in the patients at 1 year after the surgery. DSA showed the thickening of the calf and foot arteries, clear visualization, and a rich vascular network. The levels of VEGF, bFGF, and PDGF on the 11th, 18th, 28

conclusionTransverse tibial bone transport can improve the blood circulation of the affected limbs, promote the healing of diabetic foot wounds, and reduce the amputation rate of the affected limbs. Transverse tibial bone transport can promote the healing of Wagner Stage 4 diabetic foot.

Indexed as

Diabetes MellitusDiabetic FootOsteogenesis, DistractionEpidermal Growth FactorFibroblast Growth Factor 2HumansPlatelet-Derived Growth FactorTreatment OutcomeVascular Endothelial Growth Factor AEpidermal Growth FactorFibroblast Growth Factor 2Platelet-Derived Growth FactorVascular Endothelial Growth Factor Aangiogenesisdiabetic foot ulcerdistraction osteogenesistransverse tibial bone transport

Identifiers

PMID35946439
PMCPMC9483085
OpenAlexW4296326364

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.